Cargando…

The prognostic value of preoperative serum albumin in patients with bladder urothelial carcinoma undergoing transurethral resection of bladder tumor: A prospective cohort study

BACKGROUND: To evaluate whether the preoperative serum albumin level can predict the survival outcome in patients with bladder urothelial carcinoma (BUC) undergoing transurethral resection of bladder tumor (TURBT). METHODS: Four hundred fifty six newly diagnosed patients with BUC who underwent TURBT...

Descripción completa

Detalles Bibliográficos
Autores principales: Shen, Chen, Zhou, Kechong, Wang, Wei, Zhang, Yue, Liu, Xiaoqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270602/
https://www.ncbi.nlm.nih.gov/pubmed/34232194
http://dx.doi.org/10.1097/MD.0000000000026548
_version_ 1783720830116560896
author Shen, Chen
Zhou, Kechong
Wang, Wei
Zhang, Yue
Liu, Xiaoqiang
author_facet Shen, Chen
Zhou, Kechong
Wang, Wei
Zhang, Yue
Liu, Xiaoqiang
author_sort Shen, Chen
collection PubMed
description BACKGROUND: To evaluate whether the preoperative serum albumin level can predict the survival outcome in patients with bladder urothelial carcinoma (BUC) undergoing transurethral resection of bladder tumor (TURBT). METHODS: Four hundred fifty six newly diagnosed patients with BUC who underwent TURBT between January 2014 and December 2017 were retrospectively enrolled. Patients were categorized into low albumin (<40 g/L) and high albumin (≥40 g/L) groups. Survival was estimated using the Kaplan–Meier method and compared using the log-rank test. Univariate and multivariate Cox proportional analyses were used to determine the hazard ratios (HRs) for overall survival (OS). Of patients with available data, 108 (24%) and 348 (76%) patients were classified into the low albumin (<40 g/L) and high albumin (≥40 g/L) groups, respectively. RESULTS: The results of the Kaplan–Meier analysis and log-rank test showed a significantly worse 5-year OS (P = .003) in the low albumin group than in the high albumin group. In the multivariate Cox regression analysis, after adjusting for confounding variables, the preoperative albumin level remained an independent predictor for 5-year OS (HR: 0.434, 95% confidence interval: 0.221–0.852; P = .015). CONCLUSION: Our study determined that a low preoperative albumin level predicted poor OS in patients with BUC who underwent TURBT. Preoperative serum albumin is an inexpensive and easily available marker that has the potential to be a good prognostic factor for predicting mortality in patients with BUC treated with TURBT.
format Online
Article
Text
id pubmed-8270602
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-82706022021-07-12 The prognostic value of preoperative serum albumin in patients with bladder urothelial carcinoma undergoing transurethral resection of bladder tumor: A prospective cohort study Shen, Chen Zhou, Kechong Wang, Wei Zhang, Yue Liu, Xiaoqiang Medicine (Baltimore) 3700 BACKGROUND: To evaluate whether the preoperative serum albumin level can predict the survival outcome in patients with bladder urothelial carcinoma (BUC) undergoing transurethral resection of bladder tumor (TURBT). METHODS: Four hundred fifty six newly diagnosed patients with BUC who underwent TURBT between January 2014 and December 2017 were retrospectively enrolled. Patients were categorized into low albumin (<40 g/L) and high albumin (≥40 g/L) groups. Survival was estimated using the Kaplan–Meier method and compared using the log-rank test. Univariate and multivariate Cox proportional analyses were used to determine the hazard ratios (HRs) for overall survival (OS). Of patients with available data, 108 (24%) and 348 (76%) patients were classified into the low albumin (<40 g/L) and high albumin (≥40 g/L) groups, respectively. RESULTS: The results of the Kaplan–Meier analysis and log-rank test showed a significantly worse 5-year OS (P = .003) in the low albumin group than in the high albumin group. In the multivariate Cox regression analysis, after adjusting for confounding variables, the preoperative albumin level remained an independent predictor for 5-year OS (HR: 0.434, 95% confidence interval: 0.221–0.852; P = .015). CONCLUSION: Our study determined that a low preoperative albumin level predicted poor OS in patients with BUC who underwent TURBT. Preoperative serum albumin is an inexpensive and easily available marker that has the potential to be a good prognostic factor for predicting mortality in patients with BUC treated with TURBT. Lippincott Williams & Wilkins 2021-07-09 /pmc/articles/PMC8270602/ /pubmed/34232194 http://dx.doi.org/10.1097/MD.0000000000026548 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/)
spellingShingle 3700
Shen, Chen
Zhou, Kechong
Wang, Wei
Zhang, Yue
Liu, Xiaoqiang
The prognostic value of preoperative serum albumin in patients with bladder urothelial carcinoma undergoing transurethral resection of bladder tumor: A prospective cohort study
title The prognostic value of preoperative serum albumin in patients with bladder urothelial carcinoma undergoing transurethral resection of bladder tumor: A prospective cohort study
title_full The prognostic value of preoperative serum albumin in patients with bladder urothelial carcinoma undergoing transurethral resection of bladder tumor: A prospective cohort study
title_fullStr The prognostic value of preoperative serum albumin in patients with bladder urothelial carcinoma undergoing transurethral resection of bladder tumor: A prospective cohort study
title_full_unstemmed The prognostic value of preoperative serum albumin in patients with bladder urothelial carcinoma undergoing transurethral resection of bladder tumor: A prospective cohort study
title_short The prognostic value of preoperative serum albumin in patients with bladder urothelial carcinoma undergoing transurethral resection of bladder tumor: A prospective cohort study
title_sort prognostic value of preoperative serum albumin in patients with bladder urothelial carcinoma undergoing transurethral resection of bladder tumor: a prospective cohort study
topic 3700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270602/
https://www.ncbi.nlm.nih.gov/pubmed/34232194
http://dx.doi.org/10.1097/MD.0000000000026548
work_keys_str_mv AT shenchen theprognosticvalueofpreoperativeserumalbumininpatientswithbladderurothelialcarcinomaundergoingtransurethralresectionofbladdertumoraprospectivecohortstudy
AT zhoukechong theprognosticvalueofpreoperativeserumalbumininpatientswithbladderurothelialcarcinomaundergoingtransurethralresectionofbladdertumoraprospectivecohortstudy
AT wangwei theprognosticvalueofpreoperativeserumalbumininpatientswithbladderurothelialcarcinomaundergoingtransurethralresectionofbladdertumoraprospectivecohortstudy
AT zhangyue theprognosticvalueofpreoperativeserumalbumininpatientswithbladderurothelialcarcinomaundergoingtransurethralresectionofbladdertumoraprospectivecohortstudy
AT liuxiaoqiang theprognosticvalueofpreoperativeserumalbumininpatientswithbladderurothelialcarcinomaundergoingtransurethralresectionofbladdertumoraprospectivecohortstudy
AT shenchen prognosticvalueofpreoperativeserumalbumininpatientswithbladderurothelialcarcinomaundergoingtransurethralresectionofbladdertumoraprospectivecohortstudy
AT zhoukechong prognosticvalueofpreoperativeserumalbumininpatientswithbladderurothelialcarcinomaundergoingtransurethralresectionofbladdertumoraprospectivecohortstudy
AT wangwei prognosticvalueofpreoperativeserumalbumininpatientswithbladderurothelialcarcinomaundergoingtransurethralresectionofbladdertumoraprospectivecohortstudy
AT zhangyue prognosticvalueofpreoperativeserumalbumininpatientswithbladderurothelialcarcinomaundergoingtransurethralresectionofbladdertumoraprospectivecohortstudy
AT liuxiaoqiang prognosticvalueofpreoperativeserumalbumininpatientswithbladderurothelialcarcinomaundergoingtransurethralresectionofbladdertumoraprospectivecohortstudy