Transplant of SARS-CoV-2–infected Living Donor Liver: Case Report

Given the high community prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), transplant programs will encounter SARS-CoV-2 infections in living donors or recipients in the perioperative period. There is limited data on SARS-CoV-2 viremia and organotropism beyond the respirato...

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Detalles Bibliográficos
Autores principales: Nguyen, Michelle C., Lee, Eliza J., Avery, Robin K., Dioverti-Prono, M. Veronica, Shoham, Shmuel, Tobian, Aaron A. R., Bloch, Evan M., Gurakar, Ahmet, Rizkalla, Nicole A., Cameron, Andrew M., King, Elizabeth A., Ottmann, Shane, Garonzik-Wang, Jacqueline M., Wesson, Russel N., Philosophe, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Liver Transplantation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270633/
https://www.ncbi.nlm.nih.gov/pubmed/34258388
http://dx.doi.org/10.1097/TXD.0000000000001178
Descripción
Sumario:Given the high community prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), transplant programs will encounter SARS-CoV-2 infections in living donors or recipients in the perioperative period. There is limited data on SARS-CoV-2 viremia and organotropism beyond the respiratory tract to inform the risk of transplant transmission of SARS-CoV-2. We report a case of a living donor liver transplant recipient who received a right lobe graft from a living donor with symptomatic PCR-confirmed SARS-CoV-2 infection 3 d following donation. The donor was successfully treated with remdesivir, dexamethasone, and coronavirus disease 2019 (COVID-19) convalescent plasma. No viral transmission was identified, and both donor and recipient had excellent postoperative outcomes.

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