Transplant of SARS-CoV-2–infected Living Donor Liver: Case Report

Given the high community prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), transplant programs will encounter SARS-CoV-2 infections in living donors or recipients in the perioperative period. There is limited data on SARS-CoV-2 viremia and organotropism beyond the respirato...

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Autores principales: Nguyen, Michelle C., Lee, Eliza J., Avery, Robin K., Dioverti-Prono, M. Veronica, Shoham, Shmuel, Tobian, Aaron A. R., Bloch, Evan M., Gurakar, Ahmet, Rizkalla, Nicole A., Cameron, Andrew M., King, Elizabeth A., Ottmann, Shane, Garonzik-Wang, Jacqueline M., Wesson, Russel N., Philosophe, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Liver Transplantation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270633/
https://www.ncbi.nlm.nih.gov/pubmed/34258388
http://dx.doi.org/10.1097/TXD.0000000000001178
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author Nguyen, Michelle C.
Lee, Eliza J.
Avery, Robin K.
Dioverti-Prono, M. Veronica
Shoham, Shmuel
Tobian, Aaron A. R.
Bloch, Evan M.
Gurakar, Ahmet
Rizkalla, Nicole A.
Cameron, Andrew M.
King, Elizabeth A.
Ottmann, Shane
Garonzik-Wang, Jacqueline M.
Wesson, Russel N.
Philosophe, Benjamin
author_facet Nguyen, Michelle C.
Lee, Eliza J.
Avery, Robin K.
Dioverti-Prono, M. Veronica
Shoham, Shmuel
Tobian, Aaron A. R.
Bloch, Evan M.
Gurakar, Ahmet
Rizkalla, Nicole A.
Cameron, Andrew M.
King, Elizabeth A.
Ottmann, Shane
Garonzik-Wang, Jacqueline M.
Wesson, Russel N.
Philosophe, Benjamin
author_sort Nguyen, Michelle C.
collection PubMed
description Given the high community prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), transplant programs will encounter SARS-CoV-2 infections in living donors or recipients in the perioperative period. There is limited data on SARS-CoV-2 viremia and organotropism beyond the respiratory tract to inform the risk of transplant transmission of SARS-CoV-2. We report a case of a living donor liver transplant recipient who received a right lobe graft from a living donor with symptomatic PCR-confirmed SARS-CoV-2 infection 3 d following donation. The donor was successfully treated with remdesivir, dexamethasone, and coronavirus disease 2019 (COVID-19) convalescent plasma. No viral transmission was identified, and both donor and recipient had excellent postoperative outcomes.
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spelling pubmed-82706332021-07-12 Transplant of SARS-CoV-2–infected Living Donor Liver: Case Report Nguyen, Michelle C. Lee, Eliza J. Avery, Robin K. Dioverti-Prono, M. Veronica Shoham, Shmuel Tobian, Aaron A. R. Bloch, Evan M. Gurakar, Ahmet Rizkalla, Nicole A. Cameron, Andrew M. King, Elizabeth A. Ottmann, Shane Garonzik-Wang, Jacqueline M. Wesson, Russel N. Philosophe, Benjamin Transplant Direct Liver Transplantation Given the high community prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), transplant programs will encounter SARS-CoV-2 infections in living donors or recipients in the perioperative period. There is limited data on SARS-CoV-2 viremia and organotropism beyond the respiratory tract to inform the risk of transplant transmission of SARS-CoV-2. We report a case of a living donor liver transplant recipient who received a right lobe graft from a living donor with symptomatic PCR-confirmed SARS-CoV-2 infection 3 d following donation. The donor was successfully treated with remdesivir, dexamethasone, and coronavirus disease 2019 (COVID-19) convalescent plasma. No viral transmission was identified, and both donor and recipient had excellent postoperative outcomes. Lippincott Williams & Wilkins 2021-07-08 /pmc/articles/PMC8270633/ /pubmed/34258388 http://dx.doi.org/10.1097/TXD.0000000000001178 Text en Copyright © 2021 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Liver Transplantation
Nguyen, Michelle C.
Lee, Eliza J.
Avery, Robin K.
Dioverti-Prono, M. Veronica
Shoham, Shmuel
Tobian, Aaron A. R.
Bloch, Evan M.
Gurakar, Ahmet
Rizkalla, Nicole A.
Cameron, Andrew M.
King, Elizabeth A.
Ottmann, Shane
Garonzik-Wang, Jacqueline M.
Wesson, Russel N.
Philosophe, Benjamin
Transplant of SARS-CoV-2–infected Living Donor Liver: Case Report
title Transplant of SARS-CoV-2–infected Living Donor Liver: Case Report
title_full Transplant of SARS-CoV-2–infected Living Donor Liver: Case Report
title_fullStr Transplant of SARS-CoV-2–infected Living Donor Liver: Case Report
title_full_unstemmed Transplant of SARS-CoV-2–infected Living Donor Liver: Case Report
title_short Transplant of SARS-CoV-2–infected Living Donor Liver: Case Report
title_sort transplant of sars-cov-2–infected living donor liver: case report
topic Liver Transplantation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270633/
https://www.ncbi.nlm.nih.gov/pubmed/34258388
http://dx.doi.org/10.1097/TXD.0000000000001178
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