Cargando…

Short diameter may be a useful simple indicator of the tumor response in skull base meningiomas after conventionally fractionated stereotactic radiotherapy

OBJECTIVES: The purpose of this study was to assess the radiological change patterns in skull base meningiomas after conventionally fractionated stereotactic radiotherapy (CFSRT) to determine a simple and valid method to assess the tumor response. MATERIALS AND METHODS: Forty-one patients with a ben...

Descripción completa

Detalles Bibliográficos
Autores principales: Takehana, Keiichi, Nakamura, Daisuke, Abdelghaffar, Alshaymaa, Uto, Megumi, Katagiri, Tomohiro, Arakawa, Yoshiki, Mineharu, Yohei, Miyamoto, Susumu, Mizowaki, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270820/
https://www.ncbi.nlm.nih.gov/pubmed/33569622
http://dx.doi.org/10.1007/s00330-021-07707-1
_version_ 1783720873627222016
author Takehana, Keiichi
Nakamura, Daisuke
Abdelghaffar, Alshaymaa
Uto, Megumi
Katagiri, Tomohiro
Arakawa, Yoshiki
Mineharu, Yohei
Miyamoto, Susumu
Mizowaki, Takashi
author_facet Takehana, Keiichi
Nakamura, Daisuke
Abdelghaffar, Alshaymaa
Uto, Megumi
Katagiri, Tomohiro
Arakawa, Yoshiki
Mineharu, Yohei
Miyamoto, Susumu
Mizowaki, Takashi
author_sort Takehana, Keiichi
collection PubMed
description OBJECTIVES: The purpose of this study was to assess the radiological change patterns in skull base meningiomas after conventionally fractionated stereotactic radiotherapy (CFSRT) to determine a simple and valid method to assess the tumor response. MATERIALS AND METHODS: Forty-one patients with a benign skull base meningioma treated by CFSRT from March 2007 to August 2015 were retrospectively evaluated. We measured tumor volume (TV), long-axis diameter (LD), and short-axis diameter (SD) on both pre-treatment images and follow-up images of 1, 3, and 5 years after CFSRT, respectively. The paired t test was used to detect differences in the LD and SD change rates. Spearman’s correlation coefficients were calculated to evaluate relationships between the TV and the diameters changes. RESULTS: The number of available follow-up MRIs that was performed at 1, 3, and 5 years after the CFSRT was 41 (100%), 34 (83%), and 23 (56%), respectively. The change rates of SD were significantly higher than those of LD at every time point and more strongly correlated with the change rates of tumor volume at 3 and 5 years after CFSRT. CONCLUSIONS: SD may be useful as a simple indicator of the tumor response for skull base meningioma after CFSRT. KEY POINTS: • The change rate in short-axis diameter is a useful and simple indicator of the response of skull base meningioma to conventionally fractionated stereotactic radiotherapy. • Conventionally fractionated stereotactic radiotherapy for skull base meningioma achieved excellent 5-year local control. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00330-021-07707-1.
format Online
Article
Text
id pubmed-8270820
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-82708202021-07-20 Short diameter may be a useful simple indicator of the tumor response in skull base meningiomas after conventionally fractionated stereotactic radiotherapy Takehana, Keiichi Nakamura, Daisuke Abdelghaffar, Alshaymaa Uto, Megumi Katagiri, Tomohiro Arakawa, Yoshiki Mineharu, Yohei Miyamoto, Susumu Mizowaki, Takashi Eur Radiol Neuro OBJECTIVES: The purpose of this study was to assess the radiological change patterns in skull base meningiomas after conventionally fractionated stereotactic radiotherapy (CFSRT) to determine a simple and valid method to assess the tumor response. MATERIALS AND METHODS: Forty-one patients with a benign skull base meningioma treated by CFSRT from March 2007 to August 2015 were retrospectively evaluated. We measured tumor volume (TV), long-axis diameter (LD), and short-axis diameter (SD) on both pre-treatment images and follow-up images of 1, 3, and 5 years after CFSRT, respectively. The paired t test was used to detect differences in the LD and SD change rates. Spearman’s correlation coefficients were calculated to evaluate relationships between the TV and the diameters changes. RESULTS: The number of available follow-up MRIs that was performed at 1, 3, and 5 years after the CFSRT was 41 (100%), 34 (83%), and 23 (56%), respectively. The change rates of SD were significantly higher than those of LD at every time point and more strongly correlated with the change rates of tumor volume at 3 and 5 years after CFSRT. CONCLUSIONS: SD may be useful as a simple indicator of the tumor response for skull base meningioma after CFSRT. KEY POINTS: • The change rate in short-axis diameter is a useful and simple indicator of the response of skull base meningioma to conventionally fractionated stereotactic radiotherapy. • Conventionally fractionated stereotactic radiotherapy for skull base meningioma achieved excellent 5-year local control. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00330-021-07707-1. Springer Berlin Heidelberg 2021-02-10 2021 /pmc/articles/PMC8270820/ /pubmed/33569622 http://dx.doi.org/10.1007/s00330-021-07707-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Neuro
Takehana, Keiichi
Nakamura, Daisuke
Abdelghaffar, Alshaymaa
Uto, Megumi
Katagiri, Tomohiro
Arakawa, Yoshiki
Mineharu, Yohei
Miyamoto, Susumu
Mizowaki, Takashi
Short diameter may be a useful simple indicator of the tumor response in skull base meningiomas after conventionally fractionated stereotactic radiotherapy
title Short diameter may be a useful simple indicator of the tumor response in skull base meningiomas after conventionally fractionated stereotactic radiotherapy
title_full Short diameter may be a useful simple indicator of the tumor response in skull base meningiomas after conventionally fractionated stereotactic radiotherapy
title_fullStr Short diameter may be a useful simple indicator of the tumor response in skull base meningiomas after conventionally fractionated stereotactic radiotherapy
title_full_unstemmed Short diameter may be a useful simple indicator of the tumor response in skull base meningiomas after conventionally fractionated stereotactic radiotherapy
title_short Short diameter may be a useful simple indicator of the tumor response in skull base meningiomas after conventionally fractionated stereotactic radiotherapy
title_sort short diameter may be a useful simple indicator of the tumor response in skull base meningiomas after conventionally fractionated stereotactic radiotherapy
topic Neuro
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270820/
https://www.ncbi.nlm.nih.gov/pubmed/33569622
http://dx.doi.org/10.1007/s00330-021-07707-1
work_keys_str_mv AT takehanakeiichi shortdiametermaybeausefulsimpleindicatorofthetumorresponseinskullbasemeningiomasafterconventionallyfractionatedstereotacticradiotherapy
AT nakamuradaisuke shortdiametermaybeausefulsimpleindicatorofthetumorresponseinskullbasemeningiomasafterconventionallyfractionatedstereotacticradiotherapy
AT abdelghaffaralshaymaa shortdiametermaybeausefulsimpleindicatorofthetumorresponseinskullbasemeningiomasafterconventionallyfractionatedstereotacticradiotherapy
AT utomegumi shortdiametermaybeausefulsimpleindicatorofthetumorresponseinskullbasemeningiomasafterconventionallyfractionatedstereotacticradiotherapy
AT katagiritomohiro shortdiametermaybeausefulsimpleindicatorofthetumorresponseinskullbasemeningiomasafterconventionallyfractionatedstereotacticradiotherapy
AT arakawayoshiki shortdiametermaybeausefulsimpleindicatorofthetumorresponseinskullbasemeningiomasafterconventionallyfractionatedstereotacticradiotherapy
AT mineharuyohei shortdiametermaybeausefulsimpleindicatorofthetumorresponseinskullbasemeningiomasafterconventionallyfractionatedstereotacticradiotherapy
AT miyamotosusumu shortdiametermaybeausefulsimpleindicatorofthetumorresponseinskullbasemeningiomasafterconventionallyfractionatedstereotacticradiotherapy
AT mizowakitakashi shortdiametermaybeausefulsimpleindicatorofthetumorresponseinskullbasemeningiomasafterconventionallyfractionatedstereotacticradiotherapy