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Virtual magnetic resonance elastography has the feasibility to evaluate preoperative pituitary adenoma consistency
PURPOSE: To evaluate the use of preoperative virtual Magnetic Resonance Elastography (vMRE) for patients undergoing transsphenoidal resection of pituitary adenomas (PA). METHODS: Ten patients (60.2 ± 19.6 years; 8 males) were prospectively examined with the vMRE-method prior to transsphenoidal surge...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270838/ https://www.ncbi.nlm.nih.gov/pubmed/33555485 http://dx.doi.org/10.1007/s11102-021-01129-4 |
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author | Lagerstrand, Kerstin Gaedes, Nicholas Eriksson, Stig Farahmand, Dan De Coursey, Erica Johansson, Gudmundur Jönsson, Lars Skoglund, Thomas |
author_facet | Lagerstrand, Kerstin Gaedes, Nicholas Eriksson, Stig Farahmand, Dan De Coursey, Erica Johansson, Gudmundur Jönsson, Lars Skoglund, Thomas |
author_sort | Lagerstrand, Kerstin |
collection | PubMed |
description | PURPOSE: To evaluate the use of preoperative virtual Magnetic Resonance Elastography (vMRE) for patients undergoing transsphenoidal resection of pituitary adenomas (PA). METHODS: Ten patients (60.2 ± 19.6 years; 8 males) were prospectively examined with the vMRE-method prior to transsphenoidal surgery. vMRE-images, reflecting tissue stiffness were reconstructed. From these images, histograms as well as the mean stiffness values over the tumor body were extracted. Finally, vMRE-data was compared with the PA consistency at surgery blinded to vMRE. RESULTS: In all patients, successful vMRE-examination was performed enabling evaluation of even small PAs. For tumors with homogenous tissue, the mean stiffness value increased with surgical consistency grading. For heterogenous tumors, however, the mean stiffness value did not consistently reflect the grading at surgery. On the other hand, the vMRE-images and histograms were found to be able to characterize the tumor heterogeneity and display focal regions of high stiffness that were found to affect the surgery outcome in these PAs. The vMRE-images and histograms showed great promise in characterizing the consistency at surgery for these PAs. CONCLUSION: Evaluation of PA consistency in preparation for surgery seems to be feasible using the vMRE-method. Our findings also address the need for high resolution diagnostic methods that can non-invasively display focal regions of increased stiffness, as such regions may increase the difficulty of transsphenoidal PA-resection. SUPPLEMENTARY INFORMATION: The online version of this article (10.1007/s11102-021-01129-4) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-8270838 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-82708382021-07-20 Virtual magnetic resonance elastography has the feasibility to evaluate preoperative pituitary adenoma consistency Lagerstrand, Kerstin Gaedes, Nicholas Eriksson, Stig Farahmand, Dan De Coursey, Erica Johansson, Gudmundur Jönsson, Lars Skoglund, Thomas Pituitary Article PURPOSE: To evaluate the use of preoperative virtual Magnetic Resonance Elastography (vMRE) for patients undergoing transsphenoidal resection of pituitary adenomas (PA). METHODS: Ten patients (60.2 ± 19.6 years; 8 males) were prospectively examined with the vMRE-method prior to transsphenoidal surgery. vMRE-images, reflecting tissue stiffness were reconstructed. From these images, histograms as well as the mean stiffness values over the tumor body were extracted. Finally, vMRE-data was compared with the PA consistency at surgery blinded to vMRE. RESULTS: In all patients, successful vMRE-examination was performed enabling evaluation of even small PAs. For tumors with homogenous tissue, the mean stiffness value increased with surgical consistency grading. For heterogenous tumors, however, the mean stiffness value did not consistently reflect the grading at surgery. On the other hand, the vMRE-images and histograms were found to be able to characterize the tumor heterogeneity and display focal regions of high stiffness that were found to affect the surgery outcome in these PAs. The vMRE-images and histograms showed great promise in characterizing the consistency at surgery for these PAs. CONCLUSION: Evaluation of PA consistency in preparation for surgery seems to be feasible using the vMRE-method. Our findings also address the need for high resolution diagnostic methods that can non-invasively display focal regions of increased stiffness, as such regions may increase the difficulty of transsphenoidal PA-resection. SUPPLEMENTARY INFORMATION: The online version of this article (10.1007/s11102-021-01129-4) contains supplementary material, which is available to authorized users. Springer US 2021-02-08 2021 /pmc/articles/PMC8270838/ /pubmed/33555485 http://dx.doi.org/10.1007/s11102-021-01129-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Lagerstrand, Kerstin Gaedes, Nicholas Eriksson, Stig Farahmand, Dan De Coursey, Erica Johansson, Gudmundur Jönsson, Lars Skoglund, Thomas Virtual magnetic resonance elastography has the feasibility to evaluate preoperative pituitary adenoma consistency |
title | Virtual magnetic resonance elastography has the feasibility to evaluate preoperative pituitary adenoma consistency |
title_full | Virtual magnetic resonance elastography has the feasibility to evaluate preoperative pituitary adenoma consistency |
title_fullStr | Virtual magnetic resonance elastography has the feasibility to evaluate preoperative pituitary adenoma consistency |
title_full_unstemmed | Virtual magnetic resonance elastography has the feasibility to evaluate preoperative pituitary adenoma consistency |
title_short | Virtual magnetic resonance elastography has the feasibility to evaluate preoperative pituitary adenoma consistency |
title_sort | virtual magnetic resonance elastography has the feasibility to evaluate preoperative pituitary adenoma consistency |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270838/ https://www.ncbi.nlm.nih.gov/pubmed/33555485 http://dx.doi.org/10.1007/s11102-021-01129-4 |
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