Inhibition of nuclear export restores nuclear localization and residual tumor suppressor function of truncated SMARCB1/INI1 protein in a molecular subset of atypical teratoid/rhabdoid tumors

Loss of nuclear SMARCB1 (INI1/hSNF5/BAF47) protein expression due to biallelic mutations of the SMARCB1 tumor suppressor gene is a hallmark of atypical teratoid/rhabdoid tumors (ATRT), but the presence of cytoplasmic SMARCB1 protein in these tumors has not yet been described. In a series of 102 prim...

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Detalles Bibliográficos
Autores principales: Pathak, Rajiv, Zin, Francesca, Thomas, Christian, Bens, Susanne, Gayden, Tenzin, Karamchandani, Jason, Dudley, Roy W., Nemes, Karolina, Johann, Pascal D., Oyen, Florian, Kordes, Uwe, Jabado, Nada, Siebert, Reiner, Paulus, Werner, Kool, Marcel, Frühwald, Michael C., Albrecht, Steffen, Kalpana, Ganjam V., Hasselblatt, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270878/
https://www.ncbi.nlm.nih.gov/pubmed/34003336
http://dx.doi.org/10.1007/s00401-021-02328-w

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