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Coupling between the phase of a neural oscillation or bodily rhythm with behavior: Evaluation of different statistical procedures

Growing experimental evidence points at relationships between the phase of a cortical or bodily oscillation and behavior, using various circular statistical tests. Here, we systematically compare the performance (sensitivity, False Positive rate) of four circular statistical tests (some commonly use...

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Autores principales: Wolpert, Nicolai, Tallon-Baudry, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270889/
https://www.ncbi.nlm.nih.gov/pubmed/33848619
http://dx.doi.org/10.1016/j.neuroimage.2021.118050
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author Wolpert, Nicolai
Tallon-Baudry, Catherine
author_facet Wolpert, Nicolai
Tallon-Baudry, Catherine
author_sort Wolpert, Nicolai
collection PubMed
description Growing experimental evidence points at relationships between the phase of a cortical or bodily oscillation and behavior, using various circular statistical tests. Here, we systematically compare the performance (sensitivity, False Positive rate) of four circular statistical tests (some commonly used, i.e. Phase Opposition Sum, Circular Logistic Regression, others less common, i.e., Watson test, Modulation Index). We created semi-artificial datasets mimicking real two-alternative forced choice experiments with 30 participants, where we imposed a link between a simulated binary behavioral outcome with the phase of a physiological oscillation. We systematically varied the strength of phase-outcome coupling, the coupling mode (1:1 to 4:1), the overall number of trials and the relative number of trials in the two outcome conditions. We evaluated different strategies to estimate phase-outcome coupling chance level, as well as significance at the individual or group level. The results show that the Watson test, although seldom used in the experimental literature, is an excellent first intention test, with a good sensitivity and low False Positive rate, some sensitivity to 2:1 coupling mode and low computational load. Modulation Index, initially designed for continuous variables but that we find useful to estimate coupling between phase and a binary outcome, should be preferred if coupling mode is higher than 2:1. Phase Opposition Sum, coupled with a resampling procedure, is the only test retaining a good sensitivity in the case of a large unbalance in the number of occurrences of the two behavioral outcomes.
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spelling pubmed-82708892021-08-01 Coupling between the phase of a neural oscillation or bodily rhythm with behavior: Evaluation of different statistical procedures Wolpert, Nicolai Tallon-Baudry, Catherine Neuroimage Article Growing experimental evidence points at relationships between the phase of a cortical or bodily oscillation and behavior, using various circular statistical tests. Here, we systematically compare the performance (sensitivity, False Positive rate) of four circular statistical tests (some commonly used, i.e. Phase Opposition Sum, Circular Logistic Regression, others less common, i.e., Watson test, Modulation Index). We created semi-artificial datasets mimicking real two-alternative forced choice experiments with 30 participants, where we imposed a link between a simulated binary behavioral outcome with the phase of a physiological oscillation. We systematically varied the strength of phase-outcome coupling, the coupling mode (1:1 to 4:1), the overall number of trials and the relative number of trials in the two outcome conditions. We evaluated different strategies to estimate phase-outcome coupling chance level, as well as significance at the individual or group level. The results show that the Watson test, although seldom used in the experimental literature, is an excellent first intention test, with a good sensitivity and low False Positive rate, some sensitivity to 2:1 coupling mode and low computational load. Modulation Index, initially designed for continuous variables but that we find useful to estimate coupling between phase and a binary outcome, should be preferred if coupling mode is higher than 2:1. Phase Opposition Sum, coupled with a resampling procedure, is the only test retaining a good sensitivity in the case of a large unbalance in the number of occurrences of the two behavioral outcomes. Academic Press 2021-08-01 /pmc/articles/PMC8270889/ /pubmed/33848619 http://dx.doi.org/10.1016/j.neuroimage.2021.118050 Text en © 2021 The Authors. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Wolpert, Nicolai
Tallon-Baudry, Catherine
Coupling between the phase of a neural oscillation or bodily rhythm with behavior: Evaluation of different statistical procedures
title Coupling between the phase of a neural oscillation or bodily rhythm with behavior: Evaluation of different statistical procedures
title_full Coupling between the phase of a neural oscillation or bodily rhythm with behavior: Evaluation of different statistical procedures
title_fullStr Coupling between the phase of a neural oscillation or bodily rhythm with behavior: Evaluation of different statistical procedures
title_full_unstemmed Coupling between the phase of a neural oscillation or bodily rhythm with behavior: Evaluation of different statistical procedures
title_short Coupling between the phase of a neural oscillation or bodily rhythm with behavior: Evaluation of different statistical procedures
title_sort coupling between the phase of a neural oscillation or bodily rhythm with behavior: evaluation of different statistical procedures
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270889/
https://www.ncbi.nlm.nih.gov/pubmed/33848619
http://dx.doi.org/10.1016/j.neuroimage.2021.118050
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