Multiplexed functional genomic analysis of 5’ untranslated region mutations across the spectrum of prostate cancer

The functional consequences of genetic variants within 5’ untranslated regions (UTRs) on a genome-wide scale are poorly understood in disease. Here we develop a high-throughput multi-layer functional genomics method called PLUMAGE (Pooled full-length UTR Multiplex Assay on Gene Expression) to quanti...

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Detalles Bibliográficos
Autores principales: Lim, Yiting, Arora, Sonali, Schuster, Samantha L., Corey, Lukas, Fitzgibbon, Matthew, Wladyka, Cynthia L., Wu, Xiaoying, Coleman, Ilsa M., Delrow, Jeffrey J., Corey, Eva, True, Lawrence D., Nelson, Peter S., Ha, Gavin, Hsieh, Andrew C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270899/
https://www.ncbi.nlm.nih.gov/pubmed/34244513
http://dx.doi.org/10.1038/s41467-021-24445-6

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