Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine

Homozygous deletion of methylthioadenosine phosphorylase (MTAP) in cancers such as glioblastoma represents a potentially targetable vulnerability. Homozygous MTAP-deleted cell lines in culture show elevation of MTAP’s substrate metabolite, methylthioadenosine (MTA). High levels of MTA inhibit protei...

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Detalles Bibliográficos
Autores principales: Barekatain, Yasaman, Ackroyd, Jeffrey J., Yan, Victoria C., Khadka, Sunada, Wang, Lin, Chen, Ko-Chien, Poral, Anton H., Tran, Theresa, Georgiou, Dimitra K., Arthur, Kenisha, Lin, Yu-Hsi, Satani, Nikunj, Ballato, Elliot S., Behr, Eliot I., deCarvalho, Ana C., Verhaak, Roel G. W., de Groot, John, Huse, Jason T., Asara, John M., Kalluri, Raghu, Muller, Florian L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270912/
https://www.ncbi.nlm.nih.gov/pubmed/34244484
http://dx.doi.org/10.1038/s41467-021-24240-3

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