The force loading rate drives cell mechanosensing through both reinforcement and cytoskeletal softening

Cell response to force regulates essential processes in health and disease. However, the fundamental mechanical variables that cells sense and respond to remain unclear. Here we show that the rate of force application (loading rate) drives mechanosensing, as predicted by a molecular clutch model. By...

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Detalles Bibliográficos
Autores principales: Andreu, Ion, Falcones, Bryan, Hurst, Sebastian, Chahare, Nimesh, Quiroga, Xarxa, Le Roux, Anabel-Lise, Kechagia, Zanetta, Beedle, Amy E. M., Elosegui-Artola, Alberto, Trepat, Xavier, Farré, Ramon, Betz, Timo, Almendros, Isaac, Roca-Cusachs, Pere
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270983/
https://www.ncbi.nlm.nih.gov/pubmed/34244477
http://dx.doi.org/10.1038/s41467-021-24383-3

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