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TIDB: a comprehensive database of trained immunity

Trained immunity is a newly emerging concept that defines the ability of the innate immune system to form immune memory and provide long-lasting protection against previously encountered antigens. Accumulating evidence reveals that trained immunity not only has broad benefits to host defense but is...

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Detalles Bibliográficos
Autores principales: Cao, Yang, Dong, Qingyang, Wang, Dan, Liu, Ying, Zhang, Pengcheng, Yu, Xiaobo, Niu, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271126/
https://www.ncbi.nlm.nih.gov/pubmed/34244719
http://dx.doi.org/10.1093/database/baab041
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author Cao, Yang
Dong, Qingyang
Wang, Dan
Liu, Ying
Zhang, Pengcheng
Yu, Xiaobo
Niu, Chao
author_facet Cao, Yang
Dong, Qingyang
Wang, Dan
Liu, Ying
Zhang, Pengcheng
Yu, Xiaobo
Niu, Chao
author_sort Cao, Yang
collection PubMed
description Trained immunity is a newly emerging concept that defines the ability of the innate immune system to form immune memory and provide long-lasting protection against previously encountered antigens. Accumulating evidence reveals that trained immunity not only has broad benefits to host defense but is also harmful to the host in chronic inflammatory diseases. However, all trained immunity-related information is scattered in the literature and thus is difficult to access. Here, we describe Trained Immunity DataBase (TIDB), a comprehensive database that provides well-studied trained immunity-related genes from human, rat and mouse as well as the related literature evidence. Moreover, TIDB also provides three modules to analyze the function of the trained-immunity-related genes of interest, including Reactome pathway over-representation analysis, Gene Ontology enrichment analysis and protein–protein interaction subnetwork reconstruction. We believe TIDB will help developing valuable strategies for vaccine design and immune-mediated disease therapy. Database URL: http://www.ieom-tm.com/tidb
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spelling pubmed-82711262021-07-12 TIDB: a comprehensive database of trained immunity Cao, Yang Dong, Qingyang Wang, Dan Liu, Ying Zhang, Pengcheng Yu, Xiaobo Niu, Chao Database (Oxford) Original Article Trained immunity is a newly emerging concept that defines the ability of the innate immune system to form immune memory and provide long-lasting protection against previously encountered antigens. Accumulating evidence reveals that trained immunity not only has broad benefits to host defense but is also harmful to the host in chronic inflammatory diseases. However, all trained immunity-related information is scattered in the literature and thus is difficult to access. Here, we describe Trained Immunity DataBase (TIDB), a comprehensive database that provides well-studied trained immunity-related genes from human, rat and mouse as well as the related literature evidence. Moreover, TIDB also provides three modules to analyze the function of the trained-immunity-related genes of interest, including Reactome pathway over-representation analysis, Gene Ontology enrichment analysis and protein–protein interaction subnetwork reconstruction. We believe TIDB will help developing valuable strategies for vaccine design and immune-mediated disease therapy. Database URL: http://www.ieom-tm.com/tidb Oxford University Press 2021-07-09 /pmc/articles/PMC8271126/ /pubmed/34244719 http://dx.doi.org/10.1093/database/baab041 Text en © The Author(s) 2021. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Cao, Yang
Dong, Qingyang
Wang, Dan
Liu, Ying
Zhang, Pengcheng
Yu, Xiaobo
Niu, Chao
TIDB: a comprehensive database of trained immunity
title TIDB: a comprehensive database of trained immunity
title_full TIDB: a comprehensive database of trained immunity
title_fullStr TIDB: a comprehensive database of trained immunity
title_full_unstemmed TIDB: a comprehensive database of trained immunity
title_short TIDB: a comprehensive database of trained immunity
title_sort tidb: a comprehensive database of trained immunity
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271126/
https://www.ncbi.nlm.nih.gov/pubmed/34244719
http://dx.doi.org/10.1093/database/baab041
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