Is disrupted sleep a risk factor for Alzheimer’s disease? Evidence from a two-sample Mendelian randomization analysis

BACKGROUND: It is established that Alzheimer’s disease (AD) patients experience sleep disruption. However, it remains unknown whether disruption in the quantity, quality or timing of sleep is a risk factor for the onset of AD. METHODS: We used the largest published genome-wide association studies of...

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Detalles Bibliográficos
Autores principales: Anderson, Emma L, Richmond, Rebecca C, Jones, Samuel E, Hemani, Gibran, Wade, Kaitlin H, Dashti, Hassan S, Lane, Jacqueline M, Wang, Heming, Saxena, Richa, Brumpton, Ben, Korologou-Linden, Roxanna, Nielsen, Jonas B, Åsvold, Bjørn Olav, Abecasis, Gonçalo, Coulthard, Elizabeth, Kyle, Simon D, Beaumont, Robin N, Tyrrell, Jessica, Frayling, Timothy M, Munafò, Marcus R, Wood, Andrew R, Ben-Shlomo, Yoav, Howe, Laura D, Lawlor, Deborah A, Weedon, Michael N, Davey Smith, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Dementia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271193/
https://www.ncbi.nlm.nih.gov/pubmed/33150399
http://dx.doi.org/10.1093/ije/dyaa183

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