Cargando…
Thyroid Hormone Receptor Beta Inhibits PI3K-Akt-mTOR Signaling Axis in Anaplastic Thyroid Cancer via Genomic Mechanisms
Thyroid cancer is the most common endocrine malignancy, and the global incidence has increased rapidly over the past few decades. Anaplastic thyroid cancer (ATC) is highly aggressive, dedifferentiated, and patients have a median survival of fewer than 6 months. Oncogenic alterations in ATC include a...
Autores principales: | Davidson, Cole D, Bolf, Eric L, Gillis, Noelle E, Cozzens, Lauren M, Tomczak, Jennifer A, Carr, Frances E |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271203/ https://www.ncbi.nlm.nih.gov/pubmed/34258492 http://dx.doi.org/10.1210/jendso/bvab102 |
Ejemplares similares
-
SAT-571 Restoration of Thyroid Hormone Receptor Beta Signaling Reprograms Anaplastic Thyroid Cancer Cells
por: Gillis, Noelle, et al.
Publicado: (2019) -
OR21-03 Determining Novel Therapeutic Targets Using an in Vitro Model of TRb Tumor Suppression in Anaplastic Thyroid Cancer
por: Gillis, Noelle E, et al.
Publicado: (2020) -
SAT-573 Characterization of the Gene Expression Program of a Mutant Thyroid Hormone Receptor in Anaplastic Thyroid Cancer
por: Bolf, Eric, et al.
Publicado: (2019) -
Targeting Glycogen Metabolism as a Novel Therapeutic Approach in Anaplastic Thyroid Cancer
por: Davidson, Cole, et al.
Publicado: (2021) -
Thyroid Hormone Receptor Beta as Tumor Suppressor: Untapped Potential in Treatment and Diagnostics in Solid Tumors
por: Davidson, Cole D., et al.
Publicado: (2021)