A Mutation of lips-6 in C. elegans

The lips-6 gene encodes a putative lipase that plays a role in adult starvation response through a pathway that is parallel to the dauer pathway in larval Caenorhabditis elegans worms. We created a mutation of lips-6 to study its effects on lifespan and the ascaroside profile. We found that lips-6 h...

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Detalles Bibliográficos
Autores principales: Cohen, Sarah M, Le, Henry H, Sternberg, Paul W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2021
Materias:
Negative Result
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271349/
https://www.ncbi.nlm.nih.gov/pubmed/34258545
http://dx.doi.org/10.17912/micropub.biology.000419
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author Cohen, Sarah M
Le, Henry H
Sternberg, Paul W
author_facet Cohen, Sarah M
Le, Henry H
Sternberg, Paul W
author_sort Cohen, Sarah M
collection PubMed
description The lips-6 gene encodes a putative lipase that plays a role in adult starvation response through a pathway that is parallel to the dauer pathway in larval Caenorhabditis elegans worms. We created a mutation of lips-6 to study its effects on lifespan and the ascaroside profile. We found that lips-6 had a wild-type lifespan and a wild-type ascaroside profile. These results suggest that the lips-6 gene plays a minimal role in C. elegans lifespan biology and does not affect the ascaroside profile until it is specifically activated by starvation in adult worms.
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spelling pubmed-82713492021-07-12 A Mutation of lips-6 in C. elegans Cohen, Sarah M Le, Henry H Sternberg, Paul W MicroPubl Biol Negative Result The lips-6 gene encodes a putative lipase that plays a role in adult starvation response through a pathway that is parallel to the dauer pathway in larval Caenorhabditis elegans worms. We created a mutation of lips-6 to study its effects on lifespan and the ascaroside profile. We found that lips-6 had a wild-type lifespan and a wild-type ascaroside profile. These results suggest that the lips-6 gene plays a minimal role in C. elegans lifespan biology and does not affect the ascaroside profile until it is specifically activated by starvation in adult worms. Caltech Library 2021-07-09 /pmc/articles/PMC8271349/ /pubmed/34258545 http://dx.doi.org/10.17912/micropub.biology.000419 Text en Copyright: © 2021 by the authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Negative Result
Cohen, Sarah M
Le, Henry H
Sternberg, Paul W
A Mutation of lips-6 in C. elegans
title A Mutation of lips-6 in C. elegans
title_full A Mutation of lips-6 in C. elegans
title_fullStr A Mutation of lips-6 in C. elegans
title_full_unstemmed A Mutation of lips-6 in C. elegans
title_short A Mutation of lips-6 in C. elegans
title_sort mutation of lips-6 in c. elegans
topic Negative Result
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271349/
https://www.ncbi.nlm.nih.gov/pubmed/34258545
http://dx.doi.org/10.17912/micropub.biology.000419
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