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Optical Properties of Doxorubicin Hydrochloride Load and Release on Silica Nanoparticle Platform
Silica nanoparticles (SiO(2) NPs) synthesized by the Stober method were used as drug delivery vehicles. Doxorubicin hydrochloride (DOX·HCl) is a chemo-drug absorbed onto the SiO(2) NPs surfaces. The DOX·HCl loading onto and release from the SiO(2) NPs was monitored via UV-VIS and fluorescence spectr...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271519/ https://www.ncbi.nlm.nih.gov/pubmed/34209621 http://dx.doi.org/10.3390/molecules26133968 |
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author | Nguyen, Trong Nghia Nguyen, Thi Thuy Nghiem, Thi Ha Lien Nguyen, Duc Toan Tran, Thi Thu Ha Vu, Duong Nguyen, Thi Bich Ngoc Nguyen, Thi Minh Huyen Nguyen, Van Tien Nguyen, Minh Hue |
author_facet | Nguyen, Trong Nghia Nguyen, Thi Thuy Nghiem, Thi Ha Lien Nguyen, Duc Toan Tran, Thi Thu Ha Vu, Duong Nguyen, Thi Bich Ngoc Nguyen, Thi Minh Huyen Nguyen, Van Tien Nguyen, Minh Hue |
author_sort | Nguyen, Trong Nghia |
collection | PubMed |
description | Silica nanoparticles (SiO(2) NPs) synthesized by the Stober method were used as drug delivery vehicles. Doxorubicin hydrochloride (DOX·HCl) is a chemo-drug absorbed onto the SiO(2) NPs surfaces. The DOX·HCl loading onto and release from the SiO(2) NPs was monitored via UV-VIS and fluorescence spectra. Alternatively, the zeta potential was also used to monitor and evaluate the DOX·HCl loading process. The results showed that nearly 98% of DOX·HCl was effectively loaded onto the SiO(2) NPs’ surfaces by electrostatic interaction. The pH-dependence of the process wherein DOX·HCl release out of DOX·HCl-SiO(2) NPs was investigated as well. For comparison, both the free DOX·HCl molecules and DOX·HCl-SiO(2) NPs were used as the labels for cultured cancer cells. Confocal laser scanning microscopy images showed that the DOX·HCl-SiO(2) NPs were better delivered to cancer cells which are more acidic than healthy cells. We propose that engineered DOX·HCl-SiO(2) systems are good candidates for drug delivery and clinical applications. |
format | Online Article Text |
id | pubmed-8271519 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82715192021-07-11 Optical Properties of Doxorubicin Hydrochloride Load and Release on Silica Nanoparticle Platform Nguyen, Trong Nghia Nguyen, Thi Thuy Nghiem, Thi Ha Lien Nguyen, Duc Toan Tran, Thi Thu Ha Vu, Duong Nguyen, Thi Bich Ngoc Nguyen, Thi Minh Huyen Nguyen, Van Tien Nguyen, Minh Hue Molecules Article Silica nanoparticles (SiO(2) NPs) synthesized by the Stober method were used as drug delivery vehicles. Doxorubicin hydrochloride (DOX·HCl) is a chemo-drug absorbed onto the SiO(2) NPs surfaces. The DOX·HCl loading onto and release from the SiO(2) NPs was monitored via UV-VIS and fluorescence spectra. Alternatively, the zeta potential was also used to monitor and evaluate the DOX·HCl loading process. The results showed that nearly 98% of DOX·HCl was effectively loaded onto the SiO(2) NPs’ surfaces by electrostatic interaction. The pH-dependence of the process wherein DOX·HCl release out of DOX·HCl-SiO(2) NPs was investigated as well. For comparison, both the free DOX·HCl molecules and DOX·HCl-SiO(2) NPs were used as the labels for cultured cancer cells. Confocal laser scanning microscopy images showed that the DOX·HCl-SiO(2) NPs were better delivered to cancer cells which are more acidic than healthy cells. We propose that engineered DOX·HCl-SiO(2) systems are good candidates for drug delivery and clinical applications. MDPI 2021-06-29 /pmc/articles/PMC8271519/ /pubmed/34209621 http://dx.doi.org/10.3390/molecules26133968 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Nguyen, Trong Nghia Nguyen, Thi Thuy Nghiem, Thi Ha Lien Nguyen, Duc Toan Tran, Thi Thu Ha Vu, Duong Nguyen, Thi Bich Ngoc Nguyen, Thi Minh Huyen Nguyen, Van Tien Nguyen, Minh Hue Optical Properties of Doxorubicin Hydrochloride Load and Release on Silica Nanoparticle Platform |
title | Optical Properties of Doxorubicin Hydrochloride Load and Release on Silica Nanoparticle Platform |
title_full | Optical Properties of Doxorubicin Hydrochloride Load and Release on Silica Nanoparticle Platform |
title_fullStr | Optical Properties of Doxorubicin Hydrochloride Load and Release on Silica Nanoparticle Platform |
title_full_unstemmed | Optical Properties of Doxorubicin Hydrochloride Load and Release on Silica Nanoparticle Platform |
title_short | Optical Properties of Doxorubicin Hydrochloride Load and Release on Silica Nanoparticle Platform |
title_sort | optical properties of doxorubicin hydrochloride load and release on silica nanoparticle platform |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271519/ https://www.ncbi.nlm.nih.gov/pubmed/34209621 http://dx.doi.org/10.3390/molecules26133968 |
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