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Optical Properties of Doxorubicin Hydrochloride Load and Release on Silica Nanoparticle Platform

Silica nanoparticles (SiO(2) NPs) synthesized by the Stober method were used as drug delivery vehicles. Doxorubicin hydrochloride (DOX·HCl) is a chemo-drug absorbed onto the SiO(2) NPs surfaces. The DOX·HCl loading onto and release from the SiO(2) NPs was monitored via UV-VIS and fluorescence spectr...

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Autores principales: Nguyen, Trong Nghia, Nguyen, Thi Thuy, Nghiem, Thi Ha Lien, Nguyen, Duc Toan, Tran, Thi Thu Ha, Vu, Duong, Nguyen, Thi Bich Ngoc, Nguyen, Thi Minh Huyen, Nguyen, Van Tien, Nguyen, Minh Hue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271519/
https://www.ncbi.nlm.nih.gov/pubmed/34209621
http://dx.doi.org/10.3390/molecules26133968
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author Nguyen, Trong Nghia
Nguyen, Thi Thuy
Nghiem, Thi Ha Lien
Nguyen, Duc Toan
Tran, Thi Thu Ha
Vu, Duong
Nguyen, Thi Bich Ngoc
Nguyen, Thi Minh Huyen
Nguyen, Van Tien
Nguyen, Minh Hue
author_facet Nguyen, Trong Nghia
Nguyen, Thi Thuy
Nghiem, Thi Ha Lien
Nguyen, Duc Toan
Tran, Thi Thu Ha
Vu, Duong
Nguyen, Thi Bich Ngoc
Nguyen, Thi Minh Huyen
Nguyen, Van Tien
Nguyen, Minh Hue
author_sort Nguyen, Trong Nghia
collection PubMed
description Silica nanoparticles (SiO(2) NPs) synthesized by the Stober method were used as drug delivery vehicles. Doxorubicin hydrochloride (DOX·HCl) is a chemo-drug absorbed onto the SiO(2) NPs surfaces. The DOX·HCl loading onto and release from the SiO(2) NPs was monitored via UV-VIS and fluorescence spectra. Alternatively, the zeta potential was also used to monitor and evaluate the DOX·HCl loading process. The results showed that nearly 98% of DOX·HCl was effectively loaded onto the SiO(2) NPs’ surfaces by electrostatic interaction. The pH-dependence of the process wherein DOX·HCl release out of DOX·HCl-SiO(2) NPs was investigated as well. For comparison, both the free DOX·HCl molecules and DOX·HCl-SiO(2) NPs were used as the labels for cultured cancer cells. Confocal laser scanning microscopy images showed that the DOX·HCl-SiO(2) NPs were better delivered to cancer cells which are more acidic than healthy cells. We propose that engineered DOX·HCl-SiO(2) systems are good candidates for drug delivery and clinical applications.
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spelling pubmed-82715192021-07-11 Optical Properties of Doxorubicin Hydrochloride Load and Release on Silica Nanoparticle Platform Nguyen, Trong Nghia Nguyen, Thi Thuy Nghiem, Thi Ha Lien Nguyen, Duc Toan Tran, Thi Thu Ha Vu, Duong Nguyen, Thi Bich Ngoc Nguyen, Thi Minh Huyen Nguyen, Van Tien Nguyen, Minh Hue Molecules Article Silica nanoparticles (SiO(2) NPs) synthesized by the Stober method were used as drug delivery vehicles. Doxorubicin hydrochloride (DOX·HCl) is a chemo-drug absorbed onto the SiO(2) NPs surfaces. The DOX·HCl loading onto and release from the SiO(2) NPs was monitored via UV-VIS and fluorescence spectra. Alternatively, the zeta potential was also used to monitor and evaluate the DOX·HCl loading process. The results showed that nearly 98% of DOX·HCl was effectively loaded onto the SiO(2) NPs’ surfaces by electrostatic interaction. The pH-dependence of the process wherein DOX·HCl release out of DOX·HCl-SiO(2) NPs was investigated as well. For comparison, both the free DOX·HCl molecules and DOX·HCl-SiO(2) NPs were used as the labels for cultured cancer cells. Confocal laser scanning microscopy images showed that the DOX·HCl-SiO(2) NPs were better delivered to cancer cells which are more acidic than healthy cells. We propose that engineered DOX·HCl-SiO(2) systems are good candidates for drug delivery and clinical applications. MDPI 2021-06-29 /pmc/articles/PMC8271519/ /pubmed/34209621 http://dx.doi.org/10.3390/molecules26133968 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nguyen, Trong Nghia
Nguyen, Thi Thuy
Nghiem, Thi Ha Lien
Nguyen, Duc Toan
Tran, Thi Thu Ha
Vu, Duong
Nguyen, Thi Bich Ngoc
Nguyen, Thi Minh Huyen
Nguyen, Van Tien
Nguyen, Minh Hue
Optical Properties of Doxorubicin Hydrochloride Load and Release on Silica Nanoparticle Platform
title Optical Properties of Doxorubicin Hydrochloride Load and Release on Silica Nanoparticle Platform
title_full Optical Properties of Doxorubicin Hydrochloride Load and Release on Silica Nanoparticle Platform
title_fullStr Optical Properties of Doxorubicin Hydrochloride Load and Release on Silica Nanoparticle Platform
title_full_unstemmed Optical Properties of Doxorubicin Hydrochloride Load and Release on Silica Nanoparticle Platform
title_short Optical Properties of Doxorubicin Hydrochloride Load and Release on Silica Nanoparticle Platform
title_sort optical properties of doxorubicin hydrochloride load and release on silica nanoparticle platform
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271519/
https://www.ncbi.nlm.nih.gov/pubmed/34209621
http://dx.doi.org/10.3390/molecules26133968
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