Chemical Modulation of the 1-(Piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazole-2-one Scaffold as a Novel NLRP3 Inhibitor

In the search for new chemical scaffolds able to afford NLRP3 inflammasome inhibitors, we used a pharmacophore-hybridization strategy by combining the structure of the acrylic acid derivative INF39 with the 1-(piperidin-4-yl)1,3-dihydro-2H-benzo[d]imidazole-2-one substructure present in HS203873, a...

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Detalles Bibliográficos
Autores principales: Gastaldi, Simone, Boscaro, Valentina, Gianquinto, Eleonora, Sandall, Christina F., Giorgis, Marta, Marini, Elisabetta, Blua, Federica, Gallicchio, Margherita, Spyrakis, Francesca, MacDonald, Justin A., Bertinaria, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271538/
https://www.ncbi.nlm.nih.gov/pubmed/34209843
http://dx.doi.org/10.3390/molecules26133975

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