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Glochidion littorale Leaf Extract Exhibits Neuroprotective Effects in Caenorhabditis elegans via DAF-16 Activation

A number of plants used in folk medicine in Thailand and Eastern Asia are attracting interest due to the high bioactivities of their extracts. The aim of this study was to screen the edible leaf extracts of 20 plants found in Thailand and investigate the potential neuroprotective effects of the most...

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Autores principales: Bagoudou, Abdel Fawaz, Zheng, Yifeng, Nakabayashi, Masahiro, Rawdkuen, Saroat, Park, Hyun-Young, Vattem, Dhiraj A., Sato, Kenji, Nakamura, Soichiro, Katayama, Shigeru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271589/
https://www.ncbi.nlm.nih.gov/pubmed/34203560
http://dx.doi.org/10.3390/molecules26133958
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author Bagoudou, Abdel Fawaz
Zheng, Yifeng
Nakabayashi, Masahiro
Rawdkuen, Saroat
Park, Hyun-Young
Vattem, Dhiraj A.
Sato, Kenji
Nakamura, Soichiro
Katayama, Shigeru
author_facet Bagoudou, Abdel Fawaz
Zheng, Yifeng
Nakabayashi, Masahiro
Rawdkuen, Saroat
Park, Hyun-Young
Vattem, Dhiraj A.
Sato, Kenji
Nakamura, Soichiro
Katayama, Shigeru
author_sort Bagoudou, Abdel Fawaz
collection PubMed
description A number of plants used in folk medicine in Thailand and Eastern Asia are attracting interest due to the high bioactivities of their extracts. The aim of this study was to screen the edible leaf extracts of 20 plants found in Thailand and investigate the potential neuroprotective effects of the most bioactive sample. The total phenol and flavonoid content and 2,2-diphenyl-1-picrylhydrazyl radical-scavenging activity were determined for all 20 leaf extracts. Based on these assays, Glochidion littorale leaf extract (GLE), which showed a high value in all tested parameters, was used in further experiments to evaluate its effects on neurodegeneration in Caenorhabditis elegans. GLE treatment ameliorated H(2)O(2)-induced oxidative stress by attenuating the accumulation of reactive oxygen species and protected the worms against 1-methyl-4-phenylpyridinium-induced neurodegeneration. The neuroprotective effects observed may be associated with the activation of the transcription factor DAF-16. The characterization of this extract by LC-MS identified several phenolic compounds, including myricetin, coumestrin, chlorogenic acid, and hesperidin, which may play a key role in neuroprotection. This study reports the novel neuroprotective activity of GLE, which may be used to develop treatments for neurodegenerative diseases such as Parkinson’s syndrome.
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spelling pubmed-82715892021-07-11 Glochidion littorale Leaf Extract Exhibits Neuroprotective Effects in Caenorhabditis elegans via DAF-16 Activation Bagoudou, Abdel Fawaz Zheng, Yifeng Nakabayashi, Masahiro Rawdkuen, Saroat Park, Hyun-Young Vattem, Dhiraj A. Sato, Kenji Nakamura, Soichiro Katayama, Shigeru Molecules Article A number of plants used in folk medicine in Thailand and Eastern Asia are attracting interest due to the high bioactivities of their extracts. The aim of this study was to screen the edible leaf extracts of 20 plants found in Thailand and investigate the potential neuroprotective effects of the most bioactive sample. The total phenol and flavonoid content and 2,2-diphenyl-1-picrylhydrazyl radical-scavenging activity were determined for all 20 leaf extracts. Based on these assays, Glochidion littorale leaf extract (GLE), which showed a high value in all tested parameters, was used in further experiments to evaluate its effects on neurodegeneration in Caenorhabditis elegans. GLE treatment ameliorated H(2)O(2)-induced oxidative stress by attenuating the accumulation of reactive oxygen species and protected the worms against 1-methyl-4-phenylpyridinium-induced neurodegeneration. The neuroprotective effects observed may be associated with the activation of the transcription factor DAF-16. The characterization of this extract by LC-MS identified several phenolic compounds, including myricetin, coumestrin, chlorogenic acid, and hesperidin, which may play a key role in neuroprotection. This study reports the novel neuroprotective activity of GLE, which may be used to develop treatments for neurodegenerative diseases such as Parkinson’s syndrome. MDPI 2021-06-28 /pmc/articles/PMC8271589/ /pubmed/34203560 http://dx.doi.org/10.3390/molecules26133958 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bagoudou, Abdel Fawaz
Zheng, Yifeng
Nakabayashi, Masahiro
Rawdkuen, Saroat
Park, Hyun-Young
Vattem, Dhiraj A.
Sato, Kenji
Nakamura, Soichiro
Katayama, Shigeru
Glochidion littorale Leaf Extract Exhibits Neuroprotective Effects in Caenorhabditis elegans via DAF-16 Activation
title Glochidion littorale Leaf Extract Exhibits Neuroprotective Effects in Caenorhabditis elegans via DAF-16 Activation
title_full Glochidion littorale Leaf Extract Exhibits Neuroprotective Effects in Caenorhabditis elegans via DAF-16 Activation
title_fullStr Glochidion littorale Leaf Extract Exhibits Neuroprotective Effects in Caenorhabditis elegans via DAF-16 Activation
title_full_unstemmed Glochidion littorale Leaf Extract Exhibits Neuroprotective Effects in Caenorhabditis elegans via DAF-16 Activation
title_short Glochidion littorale Leaf Extract Exhibits Neuroprotective Effects in Caenorhabditis elegans via DAF-16 Activation
title_sort glochidion littorale leaf extract exhibits neuroprotective effects in caenorhabditis elegans via daf-16 activation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271589/
https://www.ncbi.nlm.nih.gov/pubmed/34203560
http://dx.doi.org/10.3390/molecules26133958
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