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Preparation and Application of Quaternized Chitosan- and AgNPs-Base Synergistic Antibacterial Hydrogel for Burn Wound Healing

Infection is the major reason that people die from burns; however, traditional medical dressings such as gauze cannot restrain bacterial growth and enhance the healing process. Herein, an organic- and inorganic-base hydrogel with antibacterial activities was designed and prepared to treat burn wound...

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Autores principales: Chen, Xushan, Zhang, Huimin, Yang, Xin, Zhang, Wuhong, Jiang, Ming, Wen, Ting, Wang, Jie, Guo, Rui, Liu, Hanjiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271850/
https://www.ncbi.nlm.nih.gov/pubmed/34279375
http://dx.doi.org/10.3390/molecules26134037
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author Chen, Xushan
Zhang, Huimin
Yang, Xin
Zhang, Wuhong
Jiang, Ming
Wen, Ting
Wang, Jie
Guo, Rui
Liu, Hanjiao
author_facet Chen, Xushan
Zhang, Huimin
Yang, Xin
Zhang, Wuhong
Jiang, Ming
Wen, Ting
Wang, Jie
Guo, Rui
Liu, Hanjiao
author_sort Chen, Xushan
collection PubMed
description Infection is the major reason that people die from burns; however, traditional medical dressings such as gauze cannot restrain bacterial growth and enhance the healing process. Herein, an organic- and inorganic-base hydrogel with antibacterial activities was designed and prepared to treat burn wounds. Oxidized dextran (ODex) and adipic dihydrazide grafted hyaluronic acid (HA-ADH) were prepared, mixed with quaternized chitosan (HACC) and silver nanoparticles to fabricate Ag@ODex/HA-ADH/HACC hydrogel. The hydrogel, composed of nature biomaterials, has a good cytocompatibility and biodegradability. Moreover, the hydrogel has an excellent antibacterial ability and presents fast healing for burn wounds compared with commercial Ag dressings. The Ag@ODex/HA-ADH/HACC hydrogel will be a promising wound dressing to repair burn wounds and will significantly decrease the possibility of bacterial infection.
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spelling pubmed-82718502021-07-11 Preparation and Application of Quaternized Chitosan- and AgNPs-Base Synergistic Antibacterial Hydrogel for Burn Wound Healing Chen, Xushan Zhang, Huimin Yang, Xin Zhang, Wuhong Jiang, Ming Wen, Ting Wang, Jie Guo, Rui Liu, Hanjiao Molecules Article Infection is the major reason that people die from burns; however, traditional medical dressings such as gauze cannot restrain bacterial growth and enhance the healing process. Herein, an organic- and inorganic-base hydrogel with antibacterial activities was designed and prepared to treat burn wounds. Oxidized dextran (ODex) and adipic dihydrazide grafted hyaluronic acid (HA-ADH) were prepared, mixed with quaternized chitosan (HACC) and silver nanoparticles to fabricate Ag@ODex/HA-ADH/HACC hydrogel. The hydrogel, composed of nature biomaterials, has a good cytocompatibility and biodegradability. Moreover, the hydrogel has an excellent antibacterial ability and presents fast healing for burn wounds compared with commercial Ag dressings. The Ag@ODex/HA-ADH/HACC hydrogel will be a promising wound dressing to repair burn wounds and will significantly decrease the possibility of bacterial infection. MDPI 2021-07-01 /pmc/articles/PMC8271850/ /pubmed/34279375 http://dx.doi.org/10.3390/molecules26134037 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Xushan
Zhang, Huimin
Yang, Xin
Zhang, Wuhong
Jiang, Ming
Wen, Ting
Wang, Jie
Guo, Rui
Liu, Hanjiao
Preparation and Application of Quaternized Chitosan- and AgNPs-Base Synergistic Antibacterial Hydrogel for Burn Wound Healing
title Preparation and Application of Quaternized Chitosan- and AgNPs-Base Synergistic Antibacterial Hydrogel for Burn Wound Healing
title_full Preparation and Application of Quaternized Chitosan- and AgNPs-Base Synergistic Antibacterial Hydrogel for Burn Wound Healing
title_fullStr Preparation and Application of Quaternized Chitosan- and AgNPs-Base Synergistic Antibacterial Hydrogel for Burn Wound Healing
title_full_unstemmed Preparation and Application of Quaternized Chitosan- and AgNPs-Base Synergistic Antibacterial Hydrogel for Burn Wound Healing
title_short Preparation and Application of Quaternized Chitosan- and AgNPs-Base Synergistic Antibacterial Hydrogel for Burn Wound Healing
title_sort preparation and application of quaternized chitosan- and agnps-base synergistic antibacterial hydrogel for burn wound healing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271850/
https://www.ncbi.nlm.nih.gov/pubmed/34279375
http://dx.doi.org/10.3390/molecules26134037
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