Cargando…
Preparation and Application of Quaternized Chitosan- and AgNPs-Base Synergistic Antibacterial Hydrogel for Burn Wound Healing
Infection is the major reason that people die from burns; however, traditional medical dressings such as gauze cannot restrain bacterial growth and enhance the healing process. Herein, an organic- and inorganic-base hydrogel with antibacterial activities was designed and prepared to treat burn wound...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271850/ https://www.ncbi.nlm.nih.gov/pubmed/34279375 http://dx.doi.org/10.3390/molecules26134037 |
_version_ | 1783721087501074432 |
---|---|
author | Chen, Xushan Zhang, Huimin Yang, Xin Zhang, Wuhong Jiang, Ming Wen, Ting Wang, Jie Guo, Rui Liu, Hanjiao |
author_facet | Chen, Xushan Zhang, Huimin Yang, Xin Zhang, Wuhong Jiang, Ming Wen, Ting Wang, Jie Guo, Rui Liu, Hanjiao |
author_sort | Chen, Xushan |
collection | PubMed |
description | Infection is the major reason that people die from burns; however, traditional medical dressings such as gauze cannot restrain bacterial growth and enhance the healing process. Herein, an organic- and inorganic-base hydrogel with antibacterial activities was designed and prepared to treat burn wounds. Oxidized dextran (ODex) and adipic dihydrazide grafted hyaluronic acid (HA-ADH) were prepared, mixed with quaternized chitosan (HACC) and silver nanoparticles to fabricate Ag@ODex/HA-ADH/HACC hydrogel. The hydrogel, composed of nature biomaterials, has a good cytocompatibility and biodegradability. Moreover, the hydrogel has an excellent antibacterial ability and presents fast healing for burn wounds compared with commercial Ag dressings. The Ag@ODex/HA-ADH/HACC hydrogel will be a promising wound dressing to repair burn wounds and will significantly decrease the possibility of bacterial infection. |
format | Online Article Text |
id | pubmed-8271850 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82718502021-07-11 Preparation and Application of Quaternized Chitosan- and AgNPs-Base Synergistic Antibacterial Hydrogel for Burn Wound Healing Chen, Xushan Zhang, Huimin Yang, Xin Zhang, Wuhong Jiang, Ming Wen, Ting Wang, Jie Guo, Rui Liu, Hanjiao Molecules Article Infection is the major reason that people die from burns; however, traditional medical dressings such as gauze cannot restrain bacterial growth and enhance the healing process. Herein, an organic- and inorganic-base hydrogel with antibacterial activities was designed and prepared to treat burn wounds. Oxidized dextran (ODex) and adipic dihydrazide grafted hyaluronic acid (HA-ADH) were prepared, mixed with quaternized chitosan (HACC) and silver nanoparticles to fabricate Ag@ODex/HA-ADH/HACC hydrogel. The hydrogel, composed of nature biomaterials, has a good cytocompatibility and biodegradability. Moreover, the hydrogel has an excellent antibacterial ability and presents fast healing for burn wounds compared with commercial Ag dressings. The Ag@ODex/HA-ADH/HACC hydrogel will be a promising wound dressing to repair burn wounds and will significantly decrease the possibility of bacterial infection. MDPI 2021-07-01 /pmc/articles/PMC8271850/ /pubmed/34279375 http://dx.doi.org/10.3390/molecules26134037 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chen, Xushan Zhang, Huimin Yang, Xin Zhang, Wuhong Jiang, Ming Wen, Ting Wang, Jie Guo, Rui Liu, Hanjiao Preparation and Application of Quaternized Chitosan- and AgNPs-Base Synergistic Antibacterial Hydrogel for Burn Wound Healing |
title | Preparation and Application of Quaternized Chitosan- and AgNPs-Base Synergistic Antibacterial Hydrogel for Burn Wound Healing |
title_full | Preparation and Application of Quaternized Chitosan- and AgNPs-Base Synergistic Antibacterial Hydrogel for Burn Wound Healing |
title_fullStr | Preparation and Application of Quaternized Chitosan- and AgNPs-Base Synergistic Antibacterial Hydrogel for Burn Wound Healing |
title_full_unstemmed | Preparation and Application of Quaternized Chitosan- and AgNPs-Base Synergistic Antibacterial Hydrogel for Burn Wound Healing |
title_short | Preparation and Application of Quaternized Chitosan- and AgNPs-Base Synergistic Antibacterial Hydrogel for Burn Wound Healing |
title_sort | preparation and application of quaternized chitosan- and agnps-base synergistic antibacterial hydrogel for burn wound healing |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271850/ https://www.ncbi.nlm.nih.gov/pubmed/34279375 http://dx.doi.org/10.3390/molecules26134037 |
work_keys_str_mv | AT chenxushan preparationandapplicationofquaternizedchitosanandagnpsbasesynergisticantibacterialhydrogelforburnwoundhealing AT zhanghuimin preparationandapplicationofquaternizedchitosanandagnpsbasesynergisticantibacterialhydrogelforburnwoundhealing AT yangxin preparationandapplicationofquaternizedchitosanandagnpsbasesynergisticantibacterialhydrogelforburnwoundhealing AT zhangwuhong preparationandapplicationofquaternizedchitosanandagnpsbasesynergisticantibacterialhydrogelforburnwoundhealing AT jiangming preparationandapplicationofquaternizedchitosanandagnpsbasesynergisticantibacterialhydrogelforburnwoundhealing AT wenting preparationandapplicationofquaternizedchitosanandagnpsbasesynergisticantibacterialhydrogelforburnwoundhealing AT wangjie preparationandapplicationofquaternizedchitosanandagnpsbasesynergisticantibacterialhydrogelforburnwoundhealing AT guorui preparationandapplicationofquaternizedchitosanandagnpsbasesynergisticantibacterialhydrogelforburnwoundhealing AT liuhanjiao preparationandapplicationofquaternizedchitosanandagnpsbasesynergisticantibacterialhydrogelforburnwoundhealing |