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Tight junction stabilization prevents HepaRG cell death in drug-induced intrahepatic cholestasis

Entacapone (ENT), a catechol-O-methyltransferase inhibitor, causes liver injury by inducing bile canaliculi (BC) dilation through inhibition of the myosin light kinase pathway. Loss of tight junctions (TJs) induces hepatocyte depolarization, which causes bile secretory failure, leading to liver dama...

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Detalles Bibliográficos
Autores principales: Sonoi, Rie, Hagihara, Yoshihisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272035/
https://www.ncbi.nlm.nih.gov/pubmed/34151938
http://dx.doi.org/10.1242/bio.058606