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Nanocelluloses: Sources, Pretreatment, Isolations, Modification, and Its Application as the Drug Carriers

The ‘Back-to-nature’ concept has currently been adopted intensively in various industries, especially the pharmaceutical industry. In the past few decades, the overuse of synthetic chemicals has caused severe damage to the environment and ecosystem. One class of natural materials developed to substi...

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Autores principales: Lunardi, Valentino Bervia, Soetaredjo, Felycia Edi, Putro, Jindrayani Nyoo, Santoso, Shella Permatasari, Yuliana, Maria, Sunarso, Jaka, Ju, Yi-Hsu, Ismadji, Suryadi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272055/
https://www.ncbi.nlm.nih.gov/pubmed/34201884
http://dx.doi.org/10.3390/polym13132052
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author Lunardi, Valentino Bervia
Soetaredjo, Felycia Edi
Putro, Jindrayani Nyoo
Santoso, Shella Permatasari
Yuliana, Maria
Sunarso, Jaka
Ju, Yi-Hsu
Ismadji, Suryadi
author_facet Lunardi, Valentino Bervia
Soetaredjo, Felycia Edi
Putro, Jindrayani Nyoo
Santoso, Shella Permatasari
Yuliana, Maria
Sunarso, Jaka
Ju, Yi-Hsu
Ismadji, Suryadi
author_sort Lunardi, Valentino Bervia
collection PubMed
description The ‘Back-to-nature’ concept has currently been adopted intensively in various industries, especially the pharmaceutical industry. In the past few decades, the overuse of synthetic chemicals has caused severe damage to the environment and ecosystem. One class of natural materials developed to substitute artificial chemicals in the pharmaceutical industries is the natural polymers, including cellulose and its derivatives. The development of nanocelluloses as nanocarriers in drug delivery systems has reached an advanced stage. Cellulose nanofiber (CNF), nanocrystal cellulose (NCC), and bacterial nanocellulose (BC) are the most common nanocellulose used as nanocarriers in drug delivery systems. Modification and functionalization using various processes and chemicals have been carried out to increase the adsorption and drug delivery performance of nanocellulose. Nanocellulose may be attached to the drug by physical interaction or chemical functionalization for covalent drug binding. Current development of nanocarrier formulations such as surfactant nanocellulose, ultra-lightweight porous materials, hydrogel, polyelectrolytes, and inorganic hybridizations has advanced to enable the construction of stimuli-responsive and specific recognition characteristics. Thus, an opportunity has emerged to develop a new generation of nanocellulose-based carriers that can modulate the drug conveyance for diverse drug characteristics. This review provides insights into selecting appropriate nanocellulose-based hybrid materials and the available modification routes to achieve satisfactory carrier performance and briefly discusses the essential criteria to achieve high-quality nanocellulose.
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spelling pubmed-82720552021-07-11 Nanocelluloses: Sources, Pretreatment, Isolations, Modification, and Its Application as the Drug Carriers Lunardi, Valentino Bervia Soetaredjo, Felycia Edi Putro, Jindrayani Nyoo Santoso, Shella Permatasari Yuliana, Maria Sunarso, Jaka Ju, Yi-Hsu Ismadji, Suryadi Polymers (Basel) Review The ‘Back-to-nature’ concept has currently been adopted intensively in various industries, especially the pharmaceutical industry. In the past few decades, the overuse of synthetic chemicals has caused severe damage to the environment and ecosystem. One class of natural materials developed to substitute artificial chemicals in the pharmaceutical industries is the natural polymers, including cellulose and its derivatives. The development of nanocelluloses as nanocarriers in drug delivery systems has reached an advanced stage. Cellulose nanofiber (CNF), nanocrystal cellulose (NCC), and bacterial nanocellulose (BC) are the most common nanocellulose used as nanocarriers in drug delivery systems. Modification and functionalization using various processes and chemicals have been carried out to increase the adsorption and drug delivery performance of nanocellulose. Nanocellulose may be attached to the drug by physical interaction or chemical functionalization for covalent drug binding. Current development of nanocarrier formulations such as surfactant nanocellulose, ultra-lightweight porous materials, hydrogel, polyelectrolytes, and inorganic hybridizations has advanced to enable the construction of stimuli-responsive and specific recognition characteristics. Thus, an opportunity has emerged to develop a new generation of nanocellulose-based carriers that can modulate the drug conveyance for diverse drug characteristics. This review provides insights into selecting appropriate nanocellulose-based hybrid materials and the available modification routes to achieve satisfactory carrier performance and briefly discusses the essential criteria to achieve high-quality nanocellulose. MDPI 2021-06-23 /pmc/articles/PMC8272055/ /pubmed/34201884 http://dx.doi.org/10.3390/polym13132052 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lunardi, Valentino Bervia
Soetaredjo, Felycia Edi
Putro, Jindrayani Nyoo
Santoso, Shella Permatasari
Yuliana, Maria
Sunarso, Jaka
Ju, Yi-Hsu
Ismadji, Suryadi
Nanocelluloses: Sources, Pretreatment, Isolations, Modification, and Its Application as the Drug Carriers
title Nanocelluloses: Sources, Pretreatment, Isolations, Modification, and Its Application as the Drug Carriers
title_full Nanocelluloses: Sources, Pretreatment, Isolations, Modification, and Its Application as the Drug Carriers
title_fullStr Nanocelluloses: Sources, Pretreatment, Isolations, Modification, and Its Application as the Drug Carriers
title_full_unstemmed Nanocelluloses: Sources, Pretreatment, Isolations, Modification, and Its Application as the Drug Carriers
title_short Nanocelluloses: Sources, Pretreatment, Isolations, Modification, and Its Application as the Drug Carriers
title_sort nanocelluloses: sources, pretreatment, isolations, modification, and its application as the drug carriers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272055/
https://www.ncbi.nlm.nih.gov/pubmed/34201884
http://dx.doi.org/10.3390/polym13132052
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