Synthesis, Enantiomeric Resolution and Biological Evaluation of HIV Capsid Inhibition Activity for Racemic, (S)- and (R)-PF74

PF74 is a capsid-targeting inhibitor of HIV replication that effectively perturbs the highly sensitive viral uncoating process. A lack of information regarding the optical purity (enantiomeric excess) of the single stereogenic centre of PF74 has resulted in ambiguity as to the potency of different s...

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Detalles Bibliográficos
Autores principales: Ruddell, Stuart, Sugrue, Elena, Memarzadeh, Sarah, Hellam, Lorna Mae, Wilson, Sam J., France, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272108/
https://www.ncbi.nlm.nih.gov/pubmed/34206893
http://dx.doi.org/10.3390/molecules26133919

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272108/
https://www.ncbi.nlm.nih.gov/pubmed/34206893
http://dx.doi.org/10.3390/molecules26133919

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