Dual DNA and protein tagging of open chromatin unveils dynamics of epigenomic landscapes in leukemia

The architecture of chromatin regulates eukaryotic cell states by controlling transcription factor access to sites of gene regulation. Here we describe a dual transposase/peroxidase approach, integrative DNA And Protein Tagging (iDAPT), which detects both DNA (iDAPT-seq) and protein (iDAPT-MS) assoc...

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Detalles Bibliográficos
Autores principales: Lee, Jonathan D., Paulo, Joao A., Posey, Ryan R., Mugoni, Vera, Kong, Nikki R., Cheloni, Giulia, Lee, Yu-Ru, Slack, Frank J., Tenen, Daniel G., Clohessy, John G., Gygi, Steven P., Pandolfi, Pier Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272231/
https://www.ncbi.nlm.nih.gov/pubmed/33649590
http://dx.doi.org/10.1038/s41592-021-01077-8

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