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Fe(3)O(4)@Pt nanoparticles to enable combinational electrodynamic/chemodynamic therapy

Electrodynamic therapy (EDT) has recently emerged as a potential external field responsive approach for tumor treatment. While it presents a number of clear superiorities, EDT inherits the intrinsic challenges of current reactive oxygen species (ROS) based therapeutic treatments owing to the complex...

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Autores principales: Chen, Tong, Chu, Qiang, Li, Mengyang, Han, Gaorong, Li, Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272323/
https://www.ncbi.nlm.nih.gov/pubmed/34246260
http://dx.doi.org/10.1186/s12951-021-00957-7
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author Chen, Tong
Chu, Qiang
Li, Mengyang
Han, Gaorong
Li, Xiang
author_facet Chen, Tong
Chu, Qiang
Li, Mengyang
Han, Gaorong
Li, Xiang
author_sort Chen, Tong
collection PubMed
description Electrodynamic therapy (EDT) has recently emerged as a potential external field responsive approach for tumor treatment. While it presents a number of clear superiorities, EDT inherits the intrinsic challenges of current reactive oxygen species (ROS) based therapeutic treatments owing to the complex tumor microenvironment, including glutathione (GSH) overexpression, acidity and others. Herein for the first time, iron oxide nanoparticles are decorated using platinum nanocrystals (Fe(3)O(4)@Pt NPs) to integrate the current EDT with chemodynamic phenomenon and GSH depletion. Fe(3)O(4)@Pt NPs can effectively induce ROS generation based on the catalytic reaction on the surface of Pt nanoparticles triggered by electric field (E), and meanwhile it may catalyze intracellular H(2)O(2) into ROS via Fenton reaction. In addition, Fe(3+) ions released from Fe(3)O(4)@Pt NPs under the acidic condition in tumor cells consume GSH in a rapid fashion, inhibiting ROS clearance to enhance its antitumor efficacy. As a result, considerable in vitro and in vivo tumor inhibition phenomena are observed. This study has demonstrated an alternative concept of combinational therapeutic modality with superior efficacy. [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12951-021-00957-7.
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spelling pubmed-82723232021-07-12 Fe(3)O(4)@Pt nanoparticles to enable combinational electrodynamic/chemodynamic therapy Chen, Tong Chu, Qiang Li, Mengyang Han, Gaorong Li, Xiang J Nanobiotechnology Research Electrodynamic therapy (EDT) has recently emerged as a potential external field responsive approach for tumor treatment. While it presents a number of clear superiorities, EDT inherits the intrinsic challenges of current reactive oxygen species (ROS) based therapeutic treatments owing to the complex tumor microenvironment, including glutathione (GSH) overexpression, acidity and others. Herein for the first time, iron oxide nanoparticles are decorated using platinum nanocrystals (Fe(3)O(4)@Pt NPs) to integrate the current EDT with chemodynamic phenomenon and GSH depletion. Fe(3)O(4)@Pt NPs can effectively induce ROS generation based on the catalytic reaction on the surface of Pt nanoparticles triggered by electric field (E), and meanwhile it may catalyze intracellular H(2)O(2) into ROS via Fenton reaction. In addition, Fe(3+) ions released from Fe(3)O(4)@Pt NPs under the acidic condition in tumor cells consume GSH in a rapid fashion, inhibiting ROS clearance to enhance its antitumor efficacy. As a result, considerable in vitro and in vivo tumor inhibition phenomena are observed. This study has demonstrated an alternative concept of combinational therapeutic modality with superior efficacy. [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12951-021-00957-7. BioMed Central 2021-07-10 /pmc/articles/PMC8272323/ /pubmed/34246260 http://dx.doi.org/10.1186/s12951-021-00957-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Chen, Tong
Chu, Qiang
Li, Mengyang
Han, Gaorong
Li, Xiang
Fe(3)O(4)@Pt nanoparticles to enable combinational electrodynamic/chemodynamic therapy
title Fe(3)O(4)@Pt nanoparticles to enable combinational electrodynamic/chemodynamic therapy
title_full Fe(3)O(4)@Pt nanoparticles to enable combinational electrodynamic/chemodynamic therapy
title_fullStr Fe(3)O(4)@Pt nanoparticles to enable combinational electrodynamic/chemodynamic therapy
title_full_unstemmed Fe(3)O(4)@Pt nanoparticles to enable combinational electrodynamic/chemodynamic therapy
title_short Fe(3)O(4)@Pt nanoparticles to enable combinational electrodynamic/chemodynamic therapy
title_sort fe(3)o(4)@pt nanoparticles to enable combinational electrodynamic/chemodynamic therapy
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272323/
https://www.ncbi.nlm.nih.gov/pubmed/34246260
http://dx.doi.org/10.1186/s12951-021-00957-7
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