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The association between Helicobacter pylori and obesity: a systematic review and meta-analysis of case–control studies

INTRODUCTION: The relationship between H. pylori infection and obesity development has remained controversial among various studies. The aim of this study was to clarify the pooled effect of H. pylori infection on the development of obesity and vice versa. METHODS: We searched international database...

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Autores principales: Baradaran, Ali, Dehghanbanadaki, Hojat, Naderpour, Sara, Pirkashani, Leila Mohammadi, Rajabi, Abdolhalim, Rashti, Roya, Riahifar, Sevda, Moradi, Yousef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272347/
https://www.ncbi.nlm.nih.gov/pubmed/34243821
http://dx.doi.org/10.1186/s40842-021-00131-w
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author Baradaran, Ali
Dehghanbanadaki, Hojat
Naderpour, Sara
Pirkashani, Leila Mohammadi
Rajabi, Abdolhalim
Rashti, Roya
Riahifar, Sevda
Moradi, Yousef
author_facet Baradaran, Ali
Dehghanbanadaki, Hojat
Naderpour, Sara
Pirkashani, Leila Mohammadi
Rajabi, Abdolhalim
Rashti, Roya
Riahifar, Sevda
Moradi, Yousef
author_sort Baradaran, Ali
collection PubMed
description INTRODUCTION: The relationship between H. pylori infection and obesity development has remained controversial among various studies. The aim of this study was to clarify the pooled effect of H. pylori infection on the development of obesity and vice versa. METHODS: We searched international databases including Medline (PubMed), Web of sciences, Scopus, EMBASE, Cochrane, Ovid, and CINHAL to retrieve all case–control studies reporting the effect of H. pylori on obesity and vice versa, which had been published in English between January 1990 and June 2019. The quality of included studies was assessed by the Modified Newcastle–Ottawa Scale for Case–Control studies. The logarithm of the odds ratio (OR) and its standard error was used for the meta-analysis. RESULTS: Eight case–control studies with 25,519 participants were included for qualitative and quantitative analyses. The pooled analysis showed that obese participants had a higher risk of H. pylori infection than lean participants with an odds ratio of 1.46 (95%CI: 1.26, 1.68). Also, the pooled analysis revealed that participants infected by H. pylori had a higher risk of obesity than non-infected participants with an odds ratio of 1.01 (95%CI: 1.01, 1.02). CONCLUSION: The results of this meta-analysis showed that there was a positive correlation between the risk of H. pylori infection and the prevalence of obesity development. Thus, H. pylori positive patients were more likely to be obese, and obese individuals had higher risks of H. pylori infection.
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spelling pubmed-82723472021-07-12 The association between Helicobacter pylori and obesity: a systematic review and meta-analysis of case–control studies Baradaran, Ali Dehghanbanadaki, Hojat Naderpour, Sara Pirkashani, Leila Mohammadi Rajabi, Abdolhalim Rashti, Roya Riahifar, Sevda Moradi, Yousef Clin Diabetes Endocrinol Research Article INTRODUCTION: The relationship between H. pylori infection and obesity development has remained controversial among various studies. The aim of this study was to clarify the pooled effect of H. pylori infection on the development of obesity and vice versa. METHODS: We searched international databases including Medline (PubMed), Web of sciences, Scopus, EMBASE, Cochrane, Ovid, and CINHAL to retrieve all case–control studies reporting the effect of H. pylori on obesity and vice versa, which had been published in English between January 1990 and June 2019. The quality of included studies was assessed by the Modified Newcastle–Ottawa Scale for Case–Control studies. The logarithm of the odds ratio (OR) and its standard error was used for the meta-analysis. RESULTS: Eight case–control studies with 25,519 participants were included for qualitative and quantitative analyses. The pooled analysis showed that obese participants had a higher risk of H. pylori infection than lean participants with an odds ratio of 1.46 (95%CI: 1.26, 1.68). Also, the pooled analysis revealed that participants infected by H. pylori had a higher risk of obesity than non-infected participants with an odds ratio of 1.01 (95%CI: 1.01, 1.02). CONCLUSION: The results of this meta-analysis showed that there was a positive correlation between the risk of H. pylori infection and the prevalence of obesity development. Thus, H. pylori positive patients were more likely to be obese, and obese individuals had higher risks of H. pylori infection. BioMed Central 2021-07-10 /pmc/articles/PMC8272347/ /pubmed/34243821 http://dx.doi.org/10.1186/s40842-021-00131-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Baradaran, Ali
Dehghanbanadaki, Hojat
Naderpour, Sara
Pirkashani, Leila Mohammadi
Rajabi, Abdolhalim
Rashti, Roya
Riahifar, Sevda
Moradi, Yousef
The association between Helicobacter pylori and obesity: a systematic review and meta-analysis of case–control studies
title The association between Helicobacter pylori and obesity: a systematic review and meta-analysis of case–control studies
title_full The association between Helicobacter pylori and obesity: a systematic review and meta-analysis of case–control studies
title_fullStr The association between Helicobacter pylori and obesity: a systematic review and meta-analysis of case–control studies
title_full_unstemmed The association between Helicobacter pylori and obesity: a systematic review and meta-analysis of case–control studies
title_short The association between Helicobacter pylori and obesity: a systematic review and meta-analysis of case–control studies
title_sort association between helicobacter pylori and obesity: a systematic review and meta-analysis of case–control studies
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272347/
https://www.ncbi.nlm.nih.gov/pubmed/34243821
http://dx.doi.org/10.1186/s40842-021-00131-w
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