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The association between Helicobacter pylori and obesity: a systematic review and meta-analysis of case–control studies
INTRODUCTION: The relationship between H. pylori infection and obesity development has remained controversial among various studies. The aim of this study was to clarify the pooled effect of H. pylori infection on the development of obesity and vice versa. METHODS: We searched international database...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272347/ https://www.ncbi.nlm.nih.gov/pubmed/34243821 http://dx.doi.org/10.1186/s40842-021-00131-w |
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author | Baradaran, Ali Dehghanbanadaki, Hojat Naderpour, Sara Pirkashani, Leila Mohammadi Rajabi, Abdolhalim Rashti, Roya Riahifar, Sevda Moradi, Yousef |
author_facet | Baradaran, Ali Dehghanbanadaki, Hojat Naderpour, Sara Pirkashani, Leila Mohammadi Rajabi, Abdolhalim Rashti, Roya Riahifar, Sevda Moradi, Yousef |
author_sort | Baradaran, Ali |
collection | PubMed |
description | INTRODUCTION: The relationship between H. pylori infection and obesity development has remained controversial among various studies. The aim of this study was to clarify the pooled effect of H. pylori infection on the development of obesity and vice versa. METHODS: We searched international databases including Medline (PubMed), Web of sciences, Scopus, EMBASE, Cochrane, Ovid, and CINHAL to retrieve all case–control studies reporting the effect of H. pylori on obesity and vice versa, which had been published in English between January 1990 and June 2019. The quality of included studies was assessed by the Modified Newcastle–Ottawa Scale for Case–Control studies. The logarithm of the odds ratio (OR) and its standard error was used for the meta-analysis. RESULTS: Eight case–control studies with 25,519 participants were included for qualitative and quantitative analyses. The pooled analysis showed that obese participants had a higher risk of H. pylori infection than lean participants with an odds ratio of 1.46 (95%CI: 1.26, 1.68). Also, the pooled analysis revealed that participants infected by H. pylori had a higher risk of obesity than non-infected participants with an odds ratio of 1.01 (95%CI: 1.01, 1.02). CONCLUSION: The results of this meta-analysis showed that there was a positive correlation between the risk of H. pylori infection and the prevalence of obesity development. Thus, H. pylori positive patients were more likely to be obese, and obese individuals had higher risks of H. pylori infection. |
format | Online Article Text |
id | pubmed-8272347 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-82723472021-07-12 The association between Helicobacter pylori and obesity: a systematic review and meta-analysis of case–control studies Baradaran, Ali Dehghanbanadaki, Hojat Naderpour, Sara Pirkashani, Leila Mohammadi Rajabi, Abdolhalim Rashti, Roya Riahifar, Sevda Moradi, Yousef Clin Diabetes Endocrinol Research Article INTRODUCTION: The relationship between H. pylori infection and obesity development has remained controversial among various studies. The aim of this study was to clarify the pooled effect of H. pylori infection on the development of obesity and vice versa. METHODS: We searched international databases including Medline (PubMed), Web of sciences, Scopus, EMBASE, Cochrane, Ovid, and CINHAL to retrieve all case–control studies reporting the effect of H. pylori on obesity and vice versa, which had been published in English between January 1990 and June 2019. The quality of included studies was assessed by the Modified Newcastle–Ottawa Scale for Case–Control studies. The logarithm of the odds ratio (OR) and its standard error was used for the meta-analysis. RESULTS: Eight case–control studies with 25,519 participants were included for qualitative and quantitative analyses. The pooled analysis showed that obese participants had a higher risk of H. pylori infection than lean participants with an odds ratio of 1.46 (95%CI: 1.26, 1.68). Also, the pooled analysis revealed that participants infected by H. pylori had a higher risk of obesity than non-infected participants with an odds ratio of 1.01 (95%CI: 1.01, 1.02). CONCLUSION: The results of this meta-analysis showed that there was a positive correlation between the risk of H. pylori infection and the prevalence of obesity development. Thus, H. pylori positive patients were more likely to be obese, and obese individuals had higher risks of H. pylori infection. BioMed Central 2021-07-10 /pmc/articles/PMC8272347/ /pubmed/34243821 http://dx.doi.org/10.1186/s40842-021-00131-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Baradaran, Ali Dehghanbanadaki, Hojat Naderpour, Sara Pirkashani, Leila Mohammadi Rajabi, Abdolhalim Rashti, Roya Riahifar, Sevda Moradi, Yousef The association between Helicobacter pylori and obesity: a systematic review and meta-analysis of case–control studies |
title | The association between Helicobacter pylori and obesity: a systematic review and meta-analysis of case–control studies |
title_full | The association between Helicobacter pylori and obesity: a systematic review and meta-analysis of case–control studies |
title_fullStr | The association between Helicobacter pylori and obesity: a systematic review and meta-analysis of case–control studies |
title_full_unstemmed | The association between Helicobacter pylori and obesity: a systematic review and meta-analysis of case–control studies |
title_short | The association between Helicobacter pylori and obesity: a systematic review and meta-analysis of case–control studies |
title_sort | association between helicobacter pylori and obesity: a systematic review and meta-analysis of case–control studies |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272347/ https://www.ncbi.nlm.nih.gov/pubmed/34243821 http://dx.doi.org/10.1186/s40842-021-00131-w |
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