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Development of a liquid biopsy based purely quantitative digital droplet PCR assay for detection of MLH1 promoter methylation in colorectal cancer patients

BACKGROUND: MutL Homolog 1 (MLH1) promotor methylation is associated with microsatellite instability high colorectal cancer (CRC). The strong correlation between methylation status and cancer development and progression has led to a growing interest in the use of methylation markers in circulating t...

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Detalles Bibliográficos
Autores principales:	Wang, Danyi, O’Rourke, Dennis, Sanchez-Garcia, Jorge F., Cai, Ti, Scheuenpflug, Juergen, Feng, Zheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272385/ https://www.ncbi.nlm.nih.gov/pubmed/34243735 http://dx.doi.org/10.1186/s12885-021-08497-x

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