Past, Present, and Future of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Ovarian Cancer

Hyperthermic intraperitoneal chemotherapy (HIPEC), along with optimal cytoreductive surgery, has been debated to be a viable option for the treatment of advanced epithelial ovarian cancer with peritoneal carcinomatosis. HIPEC is associated with a direct and improved penetration of chemotherapy drugs...

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Detalles Bibliográficos
Autores principales: Mishra, Mona, Singh, Nilanchali, Ghatage, Prafull
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Obstetrics/Gynecology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272440/
https://www.ncbi.nlm.nih.gov/pubmed/34277186
http://dx.doi.org/10.7759/cureus.15563
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author Mishra, Mona
Singh, Nilanchali
Ghatage, Prafull
author_facet Mishra, Mona
Singh, Nilanchali
Ghatage, Prafull
author_sort Mishra, Mona
collection PubMed
description Hyperthermic intraperitoneal chemotherapy (HIPEC), along with optimal cytoreductive surgery, has been debated to be a viable option for the treatment of advanced epithelial ovarian cancer with peritoneal carcinomatosis. HIPEC is associated with a direct and improved penetration of chemotherapy drugs into the affected tissue and is associated with fewer systemic side effects. There is no standard protocol for the use of HIPEC in advanced ovarian cancer. Hence, there is controversy over the timing, dose, duration, and efficacy of HIPEC. In this review, the history, technique, current evidence, recommendations, and future directions of HIPEC are discussed.
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spelling pubmed-82724402021-07-15 Past, Present, and Future of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Ovarian Cancer Mishra, Mona Singh, Nilanchali Ghatage, Prafull Cureus Obstetrics/Gynecology Hyperthermic intraperitoneal chemotherapy (HIPEC), along with optimal cytoreductive surgery, has been debated to be a viable option for the treatment of advanced epithelial ovarian cancer with peritoneal carcinomatosis. HIPEC is associated with a direct and improved penetration of chemotherapy drugs into the affected tissue and is associated with fewer systemic side effects. There is no standard protocol for the use of HIPEC in advanced ovarian cancer. Hence, there is controversy over the timing, dose, duration, and efficacy of HIPEC. In this review, the history, technique, current evidence, recommendations, and future directions of HIPEC are discussed. Cureus 2021-06-10 /pmc/articles/PMC8272440/ /pubmed/34277186 http://dx.doi.org/10.7759/cureus.15563 Text en Copyright © 2021, Mishra et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Obstetrics/Gynecology
Mishra, Mona
Singh, Nilanchali
Ghatage, Prafull
Past, Present, and Future of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Ovarian Cancer
title Past, Present, and Future of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Ovarian Cancer
title_full Past, Present, and Future of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Ovarian Cancer
title_fullStr Past, Present, and Future of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Ovarian Cancer
title_full_unstemmed Past, Present, and Future of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Ovarian Cancer
title_short Past, Present, and Future of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Ovarian Cancer
title_sort past, present, and future of hyperthermic intraperitoneal chemotherapy (hipec) in ovarian cancer
topic Obstetrics/Gynecology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272440/
https://www.ncbi.nlm.nih.gov/pubmed/34277186
http://dx.doi.org/10.7759/cureus.15563
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