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Anti-inflammatory and antiaging properties of chlorogenic acid on UV-induced fibroblast cell
BACKGROUND: Skin aging is the most common dermatological problem caused by intrinsic and extrinsic factor, such as exposure to (ultraviolet) UV rays. Chlorogenic acid (CA) is a phenolic compound which is known for its antioxidant properties against oxidative stress. OBJECTIVE: This study investigate...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PeerJ Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272460/ https://www.ncbi.nlm.nih.gov/pubmed/34277144 http://dx.doi.org/10.7717/peerj.11419 |
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author | Girsang, Ermi Ginting, Chrismis N. Lister, I Nyoman Ehrich Gunawan, Kamila yashfa Widowati, Wahyu |
author_facet | Girsang, Ermi Ginting, Chrismis N. Lister, I Nyoman Ehrich Gunawan, Kamila yashfa Widowati, Wahyu |
author_sort | Girsang, Ermi |
collection | PubMed |
description | BACKGROUND: Skin aging is the most common dermatological problem caused by intrinsic and extrinsic factor, such as exposure to (ultraviolet) UV rays. Chlorogenic acid (CA) is a phenolic compound which is known for its antioxidant properties against oxidative stress. OBJECTIVE: This study investigates the antiaging and anti-inflammatory properties of CA on UV-induced skin fibroblast cells. METHODS: Anti-inflammatory properties of CA were assessed by measuring inflammatory-related proteins IL-1β and TNF-α, while antiaging properties of CA were assessed by measuring reactive oxygen species (ROS), apoptosis, live and necrotic cells, and COL-3 gene expression level. RESULTS: Treating UV-induced skin fibroblast cells with CA decreased the level of ROS, IL-1β, TNF-α, apoptotic cells, and necrotic cells and increased live cells and COL-3 gene expression. CONCLUSION: CA has the potential as the protective compound against inflammation and aging by decreasing the level ROS, pro-inflammatory cytokines IL-1β and TNF-α, apoptotic cells, and necrotic cells and by increasing live cells and COL-3 gene expression. |
format | Online Article Text |
id | pubmed-8272460 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | PeerJ Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82724602021-07-16 Anti-inflammatory and antiaging properties of chlorogenic acid on UV-induced fibroblast cell Girsang, Ermi Ginting, Chrismis N. Lister, I Nyoman Ehrich Gunawan, Kamila yashfa Widowati, Wahyu PeerJ Cell Biology BACKGROUND: Skin aging is the most common dermatological problem caused by intrinsic and extrinsic factor, such as exposure to (ultraviolet) UV rays. Chlorogenic acid (CA) is a phenolic compound which is known for its antioxidant properties against oxidative stress. OBJECTIVE: This study investigates the antiaging and anti-inflammatory properties of CA on UV-induced skin fibroblast cells. METHODS: Anti-inflammatory properties of CA were assessed by measuring inflammatory-related proteins IL-1β and TNF-α, while antiaging properties of CA were assessed by measuring reactive oxygen species (ROS), apoptosis, live and necrotic cells, and COL-3 gene expression level. RESULTS: Treating UV-induced skin fibroblast cells with CA decreased the level of ROS, IL-1β, TNF-α, apoptotic cells, and necrotic cells and increased live cells and COL-3 gene expression. CONCLUSION: CA has the potential as the protective compound against inflammation and aging by decreasing the level ROS, pro-inflammatory cytokines IL-1β and TNF-α, apoptotic cells, and necrotic cells and by increasing live cells and COL-3 gene expression. PeerJ Inc. 2021-07-07 /pmc/articles/PMC8272460/ /pubmed/34277144 http://dx.doi.org/10.7717/peerj.11419 Text en © 2021 Girsang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. |
spellingShingle | Cell Biology Girsang, Ermi Ginting, Chrismis N. Lister, I Nyoman Ehrich Gunawan, Kamila yashfa Widowati, Wahyu Anti-inflammatory and antiaging properties of chlorogenic acid on UV-induced fibroblast cell |
title | Anti-inflammatory and antiaging properties of chlorogenic acid on UV-induced fibroblast cell |
title_full | Anti-inflammatory and antiaging properties of chlorogenic acid on UV-induced fibroblast cell |
title_fullStr | Anti-inflammatory and antiaging properties of chlorogenic acid on UV-induced fibroblast cell |
title_full_unstemmed | Anti-inflammatory and antiaging properties of chlorogenic acid on UV-induced fibroblast cell |
title_short | Anti-inflammatory and antiaging properties of chlorogenic acid on UV-induced fibroblast cell |
title_sort | anti-inflammatory and antiaging properties of chlorogenic acid on uv-induced fibroblast cell |
topic | Cell Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272460/ https://www.ncbi.nlm.nih.gov/pubmed/34277144 http://dx.doi.org/10.7717/peerj.11419 |
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