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Anti-inflammatory and antiaging properties of chlorogenic acid on UV-induced fibroblast cell

BACKGROUND: Skin aging is the most common dermatological problem caused by intrinsic and extrinsic factor, such as exposure to (ultraviolet) UV rays. Chlorogenic acid (CA) is a phenolic compound which is known for its antioxidant properties against oxidative stress. OBJECTIVE: This study investigate...

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Autores principales: Girsang, Ermi, Ginting, Chrismis N., Lister, I Nyoman Ehrich, Gunawan, Kamila yashfa, Widowati, Wahyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272460/
https://www.ncbi.nlm.nih.gov/pubmed/34277144
http://dx.doi.org/10.7717/peerj.11419
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author Girsang, Ermi
Ginting, Chrismis N.
Lister, I Nyoman Ehrich
Gunawan, Kamila yashfa
Widowati, Wahyu
author_facet Girsang, Ermi
Ginting, Chrismis N.
Lister, I Nyoman Ehrich
Gunawan, Kamila yashfa
Widowati, Wahyu
author_sort Girsang, Ermi
collection PubMed
description BACKGROUND: Skin aging is the most common dermatological problem caused by intrinsic and extrinsic factor, such as exposure to (ultraviolet) UV rays. Chlorogenic acid (CA) is a phenolic compound which is known for its antioxidant properties against oxidative stress. OBJECTIVE: This study investigates the antiaging and anti-inflammatory properties of CA on UV-induced skin fibroblast cells. METHODS: Anti-inflammatory properties of CA were assessed by measuring inflammatory-related proteins IL-1β and TNF-α, while antiaging properties of CA were assessed by measuring reactive oxygen species (ROS), apoptosis, live and necrotic cells, and COL-3 gene expression level. RESULTS: Treating UV-induced skin fibroblast cells with CA decreased the level of ROS, IL-1β, TNF-α, apoptotic cells, and necrotic cells and increased live cells and COL-3 gene expression. CONCLUSION: CA has the potential as the protective compound against inflammation and aging by decreasing the level ROS, pro-inflammatory cytokines IL-1β and TNF-α, apoptotic cells, and necrotic cells and by increasing live cells and COL-3 gene expression.
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spelling pubmed-82724602021-07-16 Anti-inflammatory and antiaging properties of chlorogenic acid on UV-induced fibroblast cell Girsang, Ermi Ginting, Chrismis N. Lister, I Nyoman Ehrich Gunawan, Kamila yashfa Widowati, Wahyu PeerJ Cell Biology BACKGROUND: Skin aging is the most common dermatological problem caused by intrinsic and extrinsic factor, such as exposure to (ultraviolet) UV rays. Chlorogenic acid (CA) is a phenolic compound which is known for its antioxidant properties against oxidative stress. OBJECTIVE: This study investigates the antiaging and anti-inflammatory properties of CA on UV-induced skin fibroblast cells. METHODS: Anti-inflammatory properties of CA were assessed by measuring inflammatory-related proteins IL-1β and TNF-α, while antiaging properties of CA were assessed by measuring reactive oxygen species (ROS), apoptosis, live and necrotic cells, and COL-3 gene expression level. RESULTS: Treating UV-induced skin fibroblast cells with CA decreased the level of ROS, IL-1β, TNF-α, apoptotic cells, and necrotic cells and increased live cells and COL-3 gene expression. CONCLUSION: CA has the potential as the protective compound against inflammation and aging by decreasing the level ROS, pro-inflammatory cytokines IL-1β and TNF-α, apoptotic cells, and necrotic cells and by increasing live cells and COL-3 gene expression. PeerJ Inc. 2021-07-07 /pmc/articles/PMC8272460/ /pubmed/34277144 http://dx.doi.org/10.7717/peerj.11419 Text en © 2021 Girsang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Cell Biology
Girsang, Ermi
Ginting, Chrismis N.
Lister, I Nyoman Ehrich
Gunawan, Kamila yashfa
Widowati, Wahyu
Anti-inflammatory and antiaging properties of chlorogenic acid on UV-induced fibroblast cell
title Anti-inflammatory and antiaging properties of chlorogenic acid on UV-induced fibroblast cell
title_full Anti-inflammatory and antiaging properties of chlorogenic acid on UV-induced fibroblast cell
title_fullStr Anti-inflammatory and antiaging properties of chlorogenic acid on UV-induced fibroblast cell
title_full_unstemmed Anti-inflammatory and antiaging properties of chlorogenic acid on UV-induced fibroblast cell
title_short Anti-inflammatory and antiaging properties of chlorogenic acid on UV-induced fibroblast cell
title_sort anti-inflammatory and antiaging properties of chlorogenic acid on uv-induced fibroblast cell
topic Cell Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272460/
https://www.ncbi.nlm.nih.gov/pubmed/34277144
http://dx.doi.org/10.7717/peerj.11419
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