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Solitary plasmacytoma of jaw bone: A case report and systematic review of fifty cases from literature

Solitary plasmacytoma of bone (SPB) is a localized form of plasma cell neoplasm where jaw involvement is rare. Distinguishing SPB from other plasma cell neoplasms is critical for treatment and survival. Here, a case of SPB of mandible in an elderly female is reported. Histopathological diagnosis of...

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Autores principales: Suryavanshi, Harshal, Patankar, Sangeeta, Dhumal, Snehal, Choudhari, Sheetal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272505/
https://www.ncbi.nlm.nih.gov/pubmed/34349446
http://dx.doi.org/10.4103/jomfp.JOMFP_251_20
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author Suryavanshi, Harshal
Patankar, Sangeeta
Dhumal, Snehal
Choudhari, Sheetal
author_facet Suryavanshi, Harshal
Patankar, Sangeeta
Dhumal, Snehal
Choudhari, Sheetal
author_sort Suryavanshi, Harshal
collection PubMed
description Solitary plasmacytoma of bone (SPB) is a localized form of plasma cell neoplasm where jaw involvement is rare. Distinguishing SPB from other plasma cell neoplasms is critical for treatment and survival. Here, a case of SPB of mandible in an elderly female is reported. Histopathological diagnosis of plasma cell neoplasm was confirmed immunohistochemically with MUM1 and CD138 positivity and multiple myeloma (MM) was ruled out on performing systemic workup. Prognosis of SPB worsens when it transforms into MM. A systematic review was undertaken with the objective to determine the factors affecting conversion of SPB to MM. An electronic search was undertaken with PubMed/MEDLINE, Web of Science and Science Direct. Fifty cases of SPB of jaw from 29 publications were reviewed. SPB commonly presents as a painless swelling. Radiographically, it is commonly seen as multilocular radiolucency with well-defined borders. Follow-up data showed that nine cases turned into MM in a mean duration of 1 year 9 months and 12 patients died after median disease-free survival of 6 years 9 months. Prognosis of SPB is found to be affected by tumor size (≥5 cm), anaplasia of tumor cells, Ki-67 labeling index, vascularity of the tumor, presence of clonal bone marrow plasma cells, serum immune globulin level, dose of radiotherapy and persistence of M protein after treatment. There is a need to identify prognostic subgroups in SPB based on these factors. Furthermore, studies are necessary for standardization of treatment protocol to halt or prolong the progression of SPB to MM.
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spelling pubmed-82725052021-08-03 Solitary plasmacytoma of jaw bone: A case report and systematic review of fifty cases from literature Suryavanshi, Harshal Patankar, Sangeeta Dhumal, Snehal Choudhari, Sheetal J Oral Maxillofac Pathol Case Report Solitary plasmacytoma of bone (SPB) is a localized form of plasma cell neoplasm where jaw involvement is rare. Distinguishing SPB from other plasma cell neoplasms is critical for treatment and survival. Here, a case of SPB of mandible in an elderly female is reported. Histopathological diagnosis of plasma cell neoplasm was confirmed immunohistochemically with MUM1 and CD138 positivity and multiple myeloma (MM) was ruled out on performing systemic workup. Prognosis of SPB worsens when it transforms into MM. A systematic review was undertaken with the objective to determine the factors affecting conversion of SPB to MM. An electronic search was undertaken with PubMed/MEDLINE, Web of Science and Science Direct. Fifty cases of SPB of jaw from 29 publications were reviewed. SPB commonly presents as a painless swelling. Radiographically, it is commonly seen as multilocular radiolucency with well-defined borders. Follow-up data showed that nine cases turned into MM in a mean duration of 1 year 9 months and 12 patients died after median disease-free survival of 6 years 9 months. Prognosis of SPB is found to be affected by tumor size (≥5 cm), anaplasia of tumor cells, Ki-67 labeling index, vascularity of the tumor, presence of clonal bone marrow plasma cells, serum immune globulin level, dose of radiotherapy and persistence of M protein after treatment. There is a need to identify prognostic subgroups in SPB based on these factors. Furthermore, studies are necessary for standardization of treatment protocol to halt or prolong the progression of SPB to MM. Wolters Kluwer - Medknow 2021 2021-05-14 /pmc/articles/PMC8272505/ /pubmed/34349446 http://dx.doi.org/10.4103/jomfp.JOMFP_251_20 Text en Copyright: © 2021 Journal of Oral and Maxillofacial Pathology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Suryavanshi, Harshal
Patankar, Sangeeta
Dhumal, Snehal
Choudhari, Sheetal
Solitary plasmacytoma of jaw bone: A case report and systematic review of fifty cases from literature
title Solitary plasmacytoma of jaw bone: A case report and systematic review of fifty cases from literature
title_full Solitary plasmacytoma of jaw bone: A case report and systematic review of fifty cases from literature
title_fullStr Solitary plasmacytoma of jaw bone: A case report and systematic review of fifty cases from literature
title_full_unstemmed Solitary plasmacytoma of jaw bone: A case report and systematic review of fifty cases from literature
title_short Solitary plasmacytoma of jaw bone: A case report and systematic review of fifty cases from literature
title_sort solitary plasmacytoma of jaw bone: a case report and systematic review of fifty cases from literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272505/
https://www.ncbi.nlm.nih.gov/pubmed/34349446
http://dx.doi.org/10.4103/jomfp.JOMFP_251_20
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