Compound NSC84167 selectively targets NRF2-activated pancreatic cancer by inhibiting asparagine synthesis pathway

Nuclear factor erythroid 2-related factor 2 (NRF2) is aberrantly activated in about 93% of pancreatic cancers. Activated NRF2 regulates multiple downstream molecules involved in cancer cell metabolic reprogramming, translational control, and treatment resistance; however, targeting NRF2 for pancreat...

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Detalles Bibliográficos
Autores principales: Dai, Bingbing, Augustine, Jithesh J., Kang, Ya’an, Roife, David, Li, Xinqun, Deng, Jenying, Tan, Lin, Rusling, Leona A., Weinstein, John N., Lorenzi, Philip L., Kim, Michael P., Fleming, Jason B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272721/
https://www.ncbi.nlm.nih.gov/pubmed/34247201
http://dx.doi.org/10.1038/s41419-021-03970-8

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