Advancing lung organoids for COVID-19 research

The COVID-19 pandemic has emphasised the need to develop effective treatments to combat emerging viruses. Model systems that poorly represent a virus' cellular environment, however, may impede research and waste resources. Collaborations between cell biologists and virologists have led to the r...

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Autores principales: van der Vaart, Jelte, Lamers, Mart M., Haagmans, Bart L., Clevers, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272930/
https://www.ncbi.nlm.nih.gov/pubmed/34219165
http://dx.doi.org/10.1242/dmm.049060
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author van der Vaart, Jelte
Lamers, Mart M.
Haagmans, Bart L.
Clevers, Hans
author_facet van der Vaart, Jelte
Lamers, Mart M.
Haagmans, Bart L.
Clevers, Hans
author_sort van der Vaart, Jelte
collection PubMed
description The COVID-19 pandemic has emphasised the need to develop effective treatments to combat emerging viruses. Model systems that poorly represent a virus' cellular environment, however, may impede research and waste resources. Collaborations between cell biologists and virologists have led to the rapid development of representative organoid model systems to study severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We believe that lung organoids, in particular, have advanced our understanding of SARS-CoV-2 pathogenesis, and have laid a foundation to study future pandemic viruses and develop effective treatments.
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spelling pubmed-82729302021-07-12 Advancing lung organoids for COVID-19 research van der Vaart, Jelte Lamers, Mart M. Haagmans, Bart L. Clevers, Hans Dis Model Mech Perspective The COVID-19 pandemic has emphasised the need to develop effective treatments to combat emerging viruses. Model systems that poorly represent a virus' cellular environment, however, may impede research and waste resources. Collaborations between cell biologists and virologists have led to the rapid development of representative organoid model systems to study severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We believe that lung organoids, in particular, have advanced our understanding of SARS-CoV-2 pathogenesis, and have laid a foundation to study future pandemic viruses and develop effective treatments. The Company of Biologists Ltd 2021-06-28 /pmc/articles/PMC8272930/ /pubmed/34219165 http://dx.doi.org/10.1242/dmm.049060 Text en © 2021. Published by The Company of Biologists Ltd https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Perspective
van der Vaart, Jelte
Lamers, Mart M.
Haagmans, Bart L.
Clevers, Hans
Advancing lung organoids for COVID-19 research
title Advancing lung organoids for COVID-19 research
title_full Advancing lung organoids for COVID-19 research
title_fullStr Advancing lung organoids for COVID-19 research
title_full_unstemmed Advancing lung organoids for COVID-19 research
title_short Advancing lung organoids for COVID-19 research
title_sort advancing lung organoids for covid-19 research
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272930/
https://www.ncbi.nlm.nih.gov/pubmed/34219165
http://dx.doi.org/10.1242/dmm.049060
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AT lamersmartm advancinglungorganoidsforcovid19research
AT haagmansbartl advancinglungorganoidsforcovid19research
AT clevershans advancinglungorganoidsforcovid19research

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