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Evaluation of A-azepano-triterpenoids and related derivatives as antimicrobial and antiviral agents

A series of semisynthetic triterpenoids with A-ring azepano- and A-seco-fragments as well as hydrazido/hydrazono-substituents at C3 and C28 has been synthesized and evaluated for antimicrobial activity against key ESKAPE pathogens and DNA viruses (HSV-1, HCMV, HPV-11). It was found that azepanouvaol...

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Detalles Bibliográficos
Autores principales: Kazakova, Oxana, Tret’yakova, Elena, Baev, Dmitry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273037/
https://www.ncbi.nlm.nih.gov/pubmed/34253887
http://dx.doi.org/10.1038/s41429-021-00448-9