Cyclic Dipeptides Formation From Linear Dipeptides Under Potentially Prebiotic Earth Conditions

Cyclic dipeptides (DKPs) are peptide precursors and chiral catalysts in the prebiotic process. This study reports proline-containing DKPs that were spontaneously obtained from linear dipeptides under an aqueous solution. Significantly, the yields of DKPs were affected by the sequence of linear dipep...

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Detalles Bibliográficos
Autores principales: Guo, Yeting, Ying, Jianxi, Sun, Dongru, Zhang, Yumeng, Zheng, Minyang, Ding, Ruiwen, Liu, Yan, Zhao, Yufen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273163/
https://www.ncbi.nlm.nih.gov/pubmed/34262893
http://dx.doi.org/10.3389/fchem.2021.675821
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author Guo, Yeting
Ying, Jianxi
Sun, Dongru
Zhang, Yumeng
Zheng, Minyang
Ding, Ruiwen
Liu, Yan
Zhao, Yufen
author_facet Guo, Yeting
Ying, Jianxi
Sun, Dongru
Zhang, Yumeng
Zheng, Minyang
Ding, Ruiwen
Liu, Yan
Zhao, Yufen
author_sort Guo, Yeting
collection PubMed
description Cyclic dipeptides (DKPs) are peptide precursors and chiral catalysts in the prebiotic process. This study reports proline-containing DKPs that were spontaneously obtained from linear dipeptides under an aqueous solution. Significantly, the yields of DKPs were affected by the sequence of linear dipeptides and whether the reaction contains trimetaphosphate. These findings provide the possibility that DKPs might play a key role in the origin of life.
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spelling pubmed-82731632021-07-13 Cyclic Dipeptides Formation From Linear Dipeptides Under Potentially Prebiotic Earth Conditions Guo, Yeting Ying, Jianxi Sun, Dongru Zhang, Yumeng Zheng, Minyang Ding, Ruiwen Liu, Yan Zhao, Yufen Front Chem Chemistry Cyclic dipeptides (DKPs) are peptide precursors and chiral catalysts in the prebiotic process. This study reports proline-containing DKPs that were spontaneously obtained from linear dipeptides under an aqueous solution. Significantly, the yields of DKPs were affected by the sequence of linear dipeptides and whether the reaction contains trimetaphosphate. These findings provide the possibility that DKPs might play a key role in the origin of life. Frontiers Media S.A. 2021-06-28 /pmc/articles/PMC8273163/ /pubmed/34262893 http://dx.doi.org/10.3389/fchem.2021.675821 Text en Copyright © 2021 Guo, Ying, Sun, Zhang, Zheng, Ding, Liu and Zhao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Guo, Yeting
Ying, Jianxi
Sun, Dongru
Zhang, Yumeng
Zheng, Minyang
Ding, Ruiwen
Liu, Yan
Zhao, Yufen
Cyclic Dipeptides Formation From Linear Dipeptides Under Potentially Prebiotic Earth Conditions
title Cyclic Dipeptides Formation From Linear Dipeptides Under Potentially Prebiotic Earth Conditions
title_full Cyclic Dipeptides Formation From Linear Dipeptides Under Potentially Prebiotic Earth Conditions
title_fullStr Cyclic Dipeptides Formation From Linear Dipeptides Under Potentially Prebiotic Earth Conditions
title_full_unstemmed Cyclic Dipeptides Formation From Linear Dipeptides Under Potentially Prebiotic Earth Conditions
title_short Cyclic Dipeptides Formation From Linear Dipeptides Under Potentially Prebiotic Earth Conditions
title_sort cyclic dipeptides formation from linear dipeptides under potentially prebiotic earth conditions
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273163/
https://www.ncbi.nlm.nih.gov/pubmed/34262893
http://dx.doi.org/10.3389/fchem.2021.675821
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