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Functional Neuroimaging During Asleep DBS Surgery: A Proof of Concept Study

Object: A real-time functional magnetic resonance imaging (fMRI) feedback during ventral intermediate nucleus (VIM) deep brain stimulation (DBS) under general anesthesia (or “asleep” DBS) does not exist. We hypothesized that it was feasible to acquire a reliable and responsive fMRI during asleep VIM...

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Autores principales: Sammartino, Francesco, Taylor, Paul, Chen, Gang, Reynolds, Richard C., Glen, Daniel, Krishna, Vibhor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273165/
https://www.ncbi.nlm.nih.gov/pubmed/34262518
http://dx.doi.org/10.3389/fneur.2021.659002
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author Sammartino, Francesco
Taylor, Paul
Chen, Gang
Reynolds, Richard C.
Glen, Daniel
Krishna, Vibhor
author_facet Sammartino, Francesco
Taylor, Paul
Chen, Gang
Reynolds, Richard C.
Glen, Daniel
Krishna, Vibhor
author_sort Sammartino, Francesco
collection PubMed
description Object: A real-time functional magnetic resonance imaging (fMRI) feedback during ventral intermediate nucleus (VIM) deep brain stimulation (DBS) under general anesthesia (or “asleep” DBS) does not exist. We hypothesized that it was feasible to acquire a reliable and responsive fMRI during asleep VIM DBS surgery. Methods: We prospectively enrolled 10 consecutive patients who underwent asleep DBS for the treatment of medication-refractory essential tremor. Under general anesthesia, we acquired resting-state functional MRI immediately before and after the cannula insertion. Reliability was determined by a temporal signal-to-noise-ratio >100. Responsiveness was determined based on the fMRI signal change upon insertion of the cannula to the VIM. Results: It was feasible to acquire reliable fMRI during asleep DBS surgery. The fMRI signal was responsive to the brain cannula insertion, revealing a reduction in the tremor network's functional connectivity, which did not reach statistical significance in the group analysis. Conclusions: It is feasible to acquire a reliable and responsive fMRI signal during asleep DBS. The acquisition steps and the preprocessing pipeline developed in these experiments will be useful for future investigations to develop fMRI-based feedback for asleep DBS surgery.
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spelling pubmed-82731652021-07-13 Functional Neuroimaging During Asleep DBS Surgery: A Proof of Concept Study Sammartino, Francesco Taylor, Paul Chen, Gang Reynolds, Richard C. Glen, Daniel Krishna, Vibhor Front Neurol Neurology Object: A real-time functional magnetic resonance imaging (fMRI) feedback during ventral intermediate nucleus (VIM) deep brain stimulation (DBS) under general anesthesia (or “asleep” DBS) does not exist. We hypothesized that it was feasible to acquire a reliable and responsive fMRI during asleep VIM DBS surgery. Methods: We prospectively enrolled 10 consecutive patients who underwent asleep DBS for the treatment of medication-refractory essential tremor. Under general anesthesia, we acquired resting-state functional MRI immediately before and after the cannula insertion. Reliability was determined by a temporal signal-to-noise-ratio >100. Responsiveness was determined based on the fMRI signal change upon insertion of the cannula to the VIM. Results: It was feasible to acquire reliable fMRI during asleep DBS surgery. The fMRI signal was responsive to the brain cannula insertion, revealing a reduction in the tremor network's functional connectivity, which did not reach statistical significance in the group analysis. Conclusions: It is feasible to acquire a reliable and responsive fMRI signal during asleep DBS. The acquisition steps and the preprocessing pipeline developed in these experiments will be useful for future investigations to develop fMRI-based feedback for asleep DBS surgery. Frontiers Media S.A. 2021-06-28 /pmc/articles/PMC8273165/ /pubmed/34262518 http://dx.doi.org/10.3389/fneur.2021.659002 Text en Copyright © 2021 Sammartino, Taylor, Chen, Reynolds, Glen and Krishna. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Sammartino, Francesco
Taylor, Paul
Chen, Gang
Reynolds, Richard C.
Glen, Daniel
Krishna, Vibhor
Functional Neuroimaging During Asleep DBS Surgery: A Proof of Concept Study
title Functional Neuroimaging During Asleep DBS Surgery: A Proof of Concept Study
title_full Functional Neuroimaging During Asleep DBS Surgery: A Proof of Concept Study
title_fullStr Functional Neuroimaging During Asleep DBS Surgery: A Proof of Concept Study
title_full_unstemmed Functional Neuroimaging During Asleep DBS Surgery: A Proof of Concept Study
title_short Functional Neuroimaging During Asleep DBS Surgery: A Proof of Concept Study
title_sort functional neuroimaging during asleep dbs surgery: a proof of concept study
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273165/
https://www.ncbi.nlm.nih.gov/pubmed/34262518
http://dx.doi.org/10.3389/fneur.2021.659002
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