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Case Report: Predominant Tubulointerstitial Lupus Nephritis or the Combination With IgG4-Related Disease?

Isolated or dominant tubulointerstitial lupus nephritis is rare. Here, we reported a 67-year-old man diagnosed with systemic lupus erythematosus (SLE) based on clinical and laboratory criteria, who was showing impaired renal function and non-nephrotic range proteinuria in the past 2 years. Renal bio...

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Autores principales: Tan, Ying, Qin, Yan, Yu, Xiao-juan, Xu, Rong, Wang, Su-xia, Zhou, Fu-de, Zhao, Ming-hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273166/
https://www.ncbi.nlm.nih.gov/pubmed/34262916
http://dx.doi.org/10.3389/fmed.2021.684889
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author Tan, Ying
Qin, Yan
Yu, Xiao-juan
Xu, Rong
Wang, Su-xia
Zhou, Fu-de
Zhao, Ming-hui
author_facet Tan, Ying
Qin, Yan
Yu, Xiao-juan
Xu, Rong
Wang, Su-xia
Zhou, Fu-de
Zhao, Ming-hui
author_sort Tan, Ying
collection PubMed
description Isolated or dominant tubulointerstitial lupus nephritis is rare. Here, we reported a 67-year-old man diagnosed with systemic lupus erythematosus (SLE) based on clinical and laboratory criteria, who was showing impaired renal function and non-nephrotic range proteinuria in the past 2 years. Renal biopsy showed almost normal glomeruli, but the tubulointerstitium showed “storiform” pattern with interstitial infiltration of IgG3 predominant plasma cells. Immunofluorescence showed linear and granular staining of IgG and C1q along TBM and interstitium. He started on medium dose of oral steroids and mycophenolate mofetil, which were gradually tapered. As a result, his renal function improved over a few days. Now, he continued on low dose steroids and mycophenolate mofetil with no evidence of relapse.
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spelling pubmed-82731662021-07-13 Case Report: Predominant Tubulointerstitial Lupus Nephritis or the Combination With IgG4-Related Disease? Tan, Ying Qin, Yan Yu, Xiao-juan Xu, Rong Wang, Su-xia Zhou, Fu-de Zhao, Ming-hui Front Med (Lausanne) Medicine Isolated or dominant tubulointerstitial lupus nephritis is rare. Here, we reported a 67-year-old man diagnosed with systemic lupus erythematosus (SLE) based on clinical and laboratory criteria, who was showing impaired renal function and non-nephrotic range proteinuria in the past 2 years. Renal biopsy showed almost normal glomeruli, but the tubulointerstitium showed “storiform” pattern with interstitial infiltration of IgG3 predominant plasma cells. Immunofluorescence showed linear and granular staining of IgG and C1q along TBM and interstitium. He started on medium dose of oral steroids and mycophenolate mofetil, which were gradually tapered. As a result, his renal function improved over a few days. Now, he continued on low dose steroids and mycophenolate mofetil with no evidence of relapse. Frontiers Media S.A. 2021-06-28 /pmc/articles/PMC8273166/ /pubmed/34262916 http://dx.doi.org/10.3389/fmed.2021.684889 Text en Copyright © 2021 Tan, Qin, Yu, Xu, Wang, Zhou and Zhao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Tan, Ying
Qin, Yan
Yu, Xiao-juan
Xu, Rong
Wang, Su-xia
Zhou, Fu-de
Zhao, Ming-hui
Case Report: Predominant Tubulointerstitial Lupus Nephritis or the Combination With IgG4-Related Disease?
title Case Report: Predominant Tubulointerstitial Lupus Nephritis or the Combination With IgG4-Related Disease?
title_full Case Report: Predominant Tubulointerstitial Lupus Nephritis or the Combination With IgG4-Related Disease?
title_fullStr Case Report: Predominant Tubulointerstitial Lupus Nephritis or the Combination With IgG4-Related Disease?
title_full_unstemmed Case Report: Predominant Tubulointerstitial Lupus Nephritis or the Combination With IgG4-Related Disease?
title_short Case Report: Predominant Tubulointerstitial Lupus Nephritis or the Combination With IgG4-Related Disease?
title_sort case report: predominant tubulointerstitial lupus nephritis or the combination with igg4-related disease?
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273166/
https://www.ncbi.nlm.nih.gov/pubmed/34262916
http://dx.doi.org/10.3389/fmed.2021.684889
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