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Novel Highly Divergent SARS-CoV-2 Lineage With the Spike Substitutions L249S and E484K
COVID-19 pandemics has led to genetic diversification of SARS-CoV-2 and the appearance of variants with potential impact in transmissibility and viral escape from acquired immunity. We report a new and highly divergent lineage containing 21 distinctive mutations (10 non-synonymous, eight synonymous,...
| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273171/ https://www.ncbi.nlm.nih.gov/pubmed/34262921 http://dx.doi.org/10.3389/fmed.2021.697605 |
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| author | Laiton-Donato, Katherine Usme-Ciro, Jose A. Franco-Muñoz, Carlos Álvarez-Díaz, Diego A. Ruiz-Moreno, Hector Alejandro Reales-González, Jhonnatan Prada, Diego Andrés Corchuelo, Sheryll Herrera-Sepúlveda, Maria T. Naizaque, Julian Santamaría, Gerardo Wiesner, Magdalena Walteros, Diana Marcela Ospina Martínez, Martha Lucia Mercado-Reyes, Marcela |
| author_facet | Laiton-Donato, Katherine Usme-Ciro, Jose A. Franco-Muñoz, Carlos Álvarez-Díaz, Diego A. Ruiz-Moreno, Hector Alejandro Reales-González, Jhonnatan Prada, Diego Andrés Corchuelo, Sheryll Herrera-Sepúlveda, Maria T. Naizaque, Julian Santamaría, Gerardo Wiesner, Magdalena Walteros, Diana Marcela Ospina Martínez, Martha Lucia Mercado-Reyes, Marcela |
| author_sort | Laiton-Donato, Katherine |
| collection | PubMed |
| description | COVID-19 pandemics has led to genetic diversification of SARS-CoV-2 and the appearance of variants with potential impact in transmissibility and viral escape from acquired immunity. We report a new and highly divergent lineage containing 21 distinctive mutations (10 non-synonymous, eight synonymous, and three substitutions in non-coding regions). The amino acid changes L249S and E484K located at the CTD and RBD of the Spike protein could be of special interest due to their potential biological role in the virus-host relationship. Further studies are required for monitoring the epidemiologic impact of this new lineage. |
| format | Online Article Text |
| id | pubmed-8273171 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Frontiers Media S.A. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-82731712021-07-13 Novel Highly Divergent SARS-CoV-2 Lineage With the Spike Substitutions L249S and E484K Laiton-Donato, Katherine Usme-Ciro, Jose A. Franco-Muñoz, Carlos Álvarez-Díaz, Diego A. Ruiz-Moreno, Hector Alejandro Reales-González, Jhonnatan Prada, Diego Andrés Corchuelo, Sheryll Herrera-Sepúlveda, Maria T. Naizaque, Julian Santamaría, Gerardo Wiesner, Magdalena Walteros, Diana Marcela Ospina Martínez, Martha Lucia Mercado-Reyes, Marcela Front Med (Lausanne) Medicine COVID-19 pandemics has led to genetic diversification of SARS-CoV-2 and the appearance of variants with potential impact in transmissibility and viral escape from acquired immunity. We report a new and highly divergent lineage containing 21 distinctive mutations (10 non-synonymous, eight synonymous, and three substitutions in non-coding regions). The amino acid changes L249S and E484K located at the CTD and RBD of the Spike protein could be of special interest due to their potential biological role in the virus-host relationship. Further studies are required for monitoring the epidemiologic impact of this new lineage. Frontiers Media S.A. 2021-06-28 /pmc/articles/PMC8273171/ /pubmed/34262921 http://dx.doi.org/10.3389/fmed.2021.697605 Text en Copyright © 2021 Laiton-Donato, Usme-Ciro, Franco-Muñoz, Álvarez-Díaz, Ruiz-Moreno, Reales-González, Prada, Corchuelo, Herrera-Sepúlveda, Naizaque, Santamaría, Wiesner, Walteros, Ospina Martínez and Mercado-Reyes. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| spellingShingle | Medicine Laiton-Donato, Katherine Usme-Ciro, Jose A. Franco-Muñoz, Carlos Álvarez-Díaz, Diego A. Ruiz-Moreno, Hector Alejandro Reales-González, Jhonnatan Prada, Diego Andrés Corchuelo, Sheryll Herrera-Sepúlveda, Maria T. Naizaque, Julian Santamaría, Gerardo Wiesner, Magdalena Walteros, Diana Marcela Ospina Martínez, Martha Lucia Mercado-Reyes, Marcela Novel Highly Divergent SARS-CoV-2 Lineage With the Spike Substitutions L249S and E484K |
| title | Novel Highly Divergent SARS-CoV-2 Lineage With the Spike Substitutions L249S and E484K |
| title_full | Novel Highly Divergent SARS-CoV-2 Lineage With the Spike Substitutions L249S and E484K |
| title_fullStr | Novel Highly Divergent SARS-CoV-2 Lineage With the Spike Substitutions L249S and E484K |
| title_full_unstemmed | Novel Highly Divergent SARS-CoV-2 Lineage With the Spike Substitutions L249S and E484K |
| title_short | Novel Highly Divergent SARS-CoV-2 Lineage With the Spike Substitutions L249S and E484K |
| title_sort | novel highly divergent sars-cov-2 lineage with the spike substitutions l249s and e484k |
| topic | Medicine |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273171/ https://www.ncbi.nlm.nih.gov/pubmed/34262921 http://dx.doi.org/10.3389/fmed.2021.697605 |
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