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Global colorectal cancer burden in 2020 and projections to 2040

As the third most common malignancy and the second most deadly cancer, colorectal cancer (CRC) induces estimated 1.9 million incidence cases and 0.9 million deaths worldwide in 2020. The incidence of CRC is higher in highly developed countries, and it is increasing in middle- and low-income countrie...

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Detalles Bibliográficos
Autores principales: Xi, Yue, Xu, Pengfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273208/
https://www.ncbi.nlm.nih.gov/pubmed/34243011
http://dx.doi.org/10.1016/j.tranon.2021.101174
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author Xi, Yue
Xu, Pengfei
author_facet Xi, Yue
Xu, Pengfei
author_sort Xi, Yue
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description As the third most common malignancy and the second most deadly cancer, colorectal cancer (CRC) induces estimated 1.9 million incidence cases and 0.9 million deaths worldwide in 2020. The incidence of CRC is higher in highly developed countries, and it is increasing in middle- and low-income countries due to westernization. Moreover, a rising incidence of early-onset CRC is also emerging. The large number of CRC cases poses a growing global public health challenge. Raising awareness of CRC is important to promote healthy lifestyle choices, novel strategies for CRC management, and implementation of global screening programs, which are critical to reducing CRC morbidity and mortality in the future. CRC is a heterogeneous disease, and its subtype affiliation influences prognosis and therapeutic response. An accurate CRC subtype classification system is of great significance for basic research and clinical outcome. Here, we present the global epidemiology of CRC in 2020 and projections for 2040, review the major CRC subtypes to better understand CRC molecular basis, and summarize current risk factors, prevention, and screening strategies for CRC.
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spelling pubmed-82732082021-07-22 Global colorectal cancer burden in 2020 and projections to 2040 Xi, Yue Xu, Pengfei Transl Oncol Review As the third most common malignancy and the second most deadly cancer, colorectal cancer (CRC) induces estimated 1.9 million incidence cases and 0.9 million deaths worldwide in 2020. The incidence of CRC is higher in highly developed countries, and it is increasing in middle- and low-income countries due to westernization. Moreover, a rising incidence of early-onset CRC is also emerging. The large number of CRC cases poses a growing global public health challenge. Raising awareness of CRC is important to promote healthy lifestyle choices, novel strategies for CRC management, and implementation of global screening programs, which are critical to reducing CRC morbidity and mortality in the future. CRC is a heterogeneous disease, and its subtype affiliation influences prognosis and therapeutic response. An accurate CRC subtype classification system is of great significance for basic research and clinical outcome. Here, we present the global epidemiology of CRC in 2020 and projections for 2040, review the major CRC subtypes to better understand CRC molecular basis, and summarize current risk factors, prevention, and screening strategies for CRC. Neoplasia Press 2021-07-06 /pmc/articles/PMC8273208/ /pubmed/34243011 http://dx.doi.org/10.1016/j.tranon.2021.101174 Text en © 2021 The Authors. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Xi, Yue
Xu, Pengfei
Global colorectal cancer burden in 2020 and projections to 2040
title Global colorectal cancer burden in 2020 and projections to 2040
title_full Global colorectal cancer burden in 2020 and projections to 2040
title_fullStr Global colorectal cancer burden in 2020 and projections to 2040
title_full_unstemmed Global colorectal cancer burden in 2020 and projections to 2040
title_short Global colorectal cancer burden in 2020 and projections to 2040
title_sort global colorectal cancer burden in 2020 and projections to 2040
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273208/
https://www.ncbi.nlm.nih.gov/pubmed/34243011
http://dx.doi.org/10.1016/j.tranon.2021.101174
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