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White Matter Hyperintensities Are Associated With Severity of Essential Tremor in the Elderly
Background: Essential tremor (ET) occurs with steeply increasing prevalence in the elderly, and apart from disease duration, age is independently associated with an increase of tremor amplitude and a decrease of frequency. White matter hyperintensities (WMHs) are a common finding in the elderly, and...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273287/ https://www.ncbi.nlm.nih.gov/pubmed/34262526 http://dx.doi.org/10.3389/fneur.2021.694286 |
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author | Becktepe, Jos S. Busse, Johannes Jensen-Kondering, Ulf Toedt, Inken Wolff, Stephan Zeuner, Kirsten E. Berg, Daniela Granert, Oliver Deuschl, Günther |
author_facet | Becktepe, Jos S. Busse, Johannes Jensen-Kondering, Ulf Toedt, Inken Wolff, Stephan Zeuner, Kirsten E. Berg, Daniela Granert, Oliver Deuschl, Günther |
author_sort | Becktepe, Jos S. |
collection | PubMed |
description | Background: Essential tremor (ET) occurs with steeply increasing prevalence in the elderly, and apart from disease duration, age is independently associated with an increase of tremor amplitude and a decrease of frequency. White matter hyperintensities (WMHs) are a common finding in the elderly, and their role in the pathophysiology of ET is unknown. The aims of this study were to examine whether ET patients differ in their total or region-specific WMH volumes from healthy controls and to determine the impact of WMH on tremor characteristics. Methods: A total of 47 elderly ET patients with a mean age of 72 years and 39 age-matched healthy controls underwent a thorough clinical assessment and 3T MRI. Total WMH volumes were derived from T2-weighted fluid-attenuated inversion recovery (FLAIR) MR images. Additionally, region of interest-based WMH volumes for the Johns Hopkins University (JHU) white matter tracts and labels were calculated, and WMHs were assessed semiquantitatively using the Fazekas scale. Results: Essential tremor patients and healthy controls did not differ in their total or tract-specific WMH volumes or Fazekas scores. However, WMH volume was significantly positively correlated with tremor severity on the TETRAS scale, and there was a significant negative correlation with the mean accelerometric tremor frequency. In a multiple linear regression model including disease duration, age, and age-adjusted total WMH volume, only the WMH volume significantly predicted tremor severity, while age and disease duration were not significant. Conclusion: We found evidence for a direct association between WMH volume and tremor severity. If confirmed by larger studies, our findings could explain the well-known relation between age and tremor severity. |
format | Online Article Text |
id | pubmed-8273287 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82732872021-07-13 White Matter Hyperintensities Are Associated With Severity of Essential Tremor in the Elderly Becktepe, Jos S. Busse, Johannes Jensen-Kondering, Ulf Toedt, Inken Wolff, Stephan Zeuner, Kirsten E. Berg, Daniela Granert, Oliver Deuschl, Günther Front Neurol Neurology Background: Essential tremor (ET) occurs with steeply increasing prevalence in the elderly, and apart from disease duration, age is independently associated with an increase of tremor amplitude and a decrease of frequency. White matter hyperintensities (WMHs) are a common finding in the elderly, and their role in the pathophysiology of ET is unknown. The aims of this study were to examine whether ET patients differ in their total or region-specific WMH volumes from healthy controls and to determine the impact of WMH on tremor characteristics. Methods: A total of 47 elderly ET patients with a mean age of 72 years and 39 age-matched healthy controls underwent a thorough clinical assessment and 3T MRI. Total WMH volumes were derived from T2-weighted fluid-attenuated inversion recovery (FLAIR) MR images. Additionally, region of interest-based WMH volumes for the Johns Hopkins University (JHU) white matter tracts and labels were calculated, and WMHs were assessed semiquantitatively using the Fazekas scale. Results: Essential tremor patients and healthy controls did not differ in their total or tract-specific WMH volumes or Fazekas scores. However, WMH volume was significantly positively correlated with tremor severity on the TETRAS scale, and there was a significant negative correlation with the mean accelerometric tremor frequency. In a multiple linear regression model including disease duration, age, and age-adjusted total WMH volume, only the WMH volume significantly predicted tremor severity, while age and disease duration were not significant. Conclusion: We found evidence for a direct association between WMH volume and tremor severity. If confirmed by larger studies, our findings could explain the well-known relation between age and tremor severity. Frontiers Media S.A. 2021-06-28 /pmc/articles/PMC8273287/ /pubmed/34262526 http://dx.doi.org/10.3389/fneur.2021.694286 Text en Copyright © 2021 Becktepe, Busse, Jensen-Kondering, Toedt, Wolff, Zeuner, Berg, Granert and Deuschl. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Becktepe, Jos S. Busse, Johannes Jensen-Kondering, Ulf Toedt, Inken Wolff, Stephan Zeuner, Kirsten E. Berg, Daniela Granert, Oliver Deuschl, Günther White Matter Hyperintensities Are Associated With Severity of Essential Tremor in the Elderly |
title | White Matter Hyperintensities Are Associated With Severity of Essential Tremor in the Elderly |
title_full | White Matter Hyperintensities Are Associated With Severity of Essential Tremor in the Elderly |
title_fullStr | White Matter Hyperintensities Are Associated With Severity of Essential Tremor in the Elderly |
title_full_unstemmed | White Matter Hyperintensities Are Associated With Severity of Essential Tremor in the Elderly |
title_short | White Matter Hyperintensities Are Associated With Severity of Essential Tremor in the Elderly |
title_sort | white matter hyperintensities are associated with severity of essential tremor in the elderly |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273287/ https://www.ncbi.nlm.nih.gov/pubmed/34262526 http://dx.doi.org/10.3389/fneur.2021.694286 |
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