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Antisense Oligonucleotide-Mediated Reduction of HDAC6 Does Not Reduce Tau Pathology in P301S Tau Transgenic Mice

Acetylation of tau protein is dysregulated in Alzheimer's Disease (AD). It has been proposed that acetylation of specific sites in the KXGS motif of tau can regulate phosphorylation of nearby residues and reduce the propensity of tau to aggregate. Histone deacetylase 6 (HDAC6) is a cytoplasmic...

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Detalles Bibliográficos
Autores principales:	Valencia, Antonio, Bieber, Veronica L. Reinhart, Bajrami, Bekim, Marsh, Galina, Hamann, Stefan, Wei, Ru, Ling, Karen, Rigo, Frank, Arnold, H. Moore, Golonzhka, Olga, Hering, Heike
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Neurology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273312/ https://www.ncbi.nlm.nih.gov/pubmed/34262517 http://dx.doi.org/10.3389/fneur.2021.624051

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