Cargando…

Clinical, Radiometabolic and Immunologic Effects of Olaparib in Locally Advanced Triple Negative Breast Cancer: The OLTRE Window of Opportunity Trial

INTRODUCTION: Olaparib is effective in metastatic triple negative breast cancer (TNBC) carrying germline mutations in DNA damage repair (DDR) genes BRCA1/2 (gBRCA-mut). The OLTRE window-of-opportunity trial preliminarily investigated potential pathologic, radiometabolic and immune biomarkers of earl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schettini, Francesco, Corona, Silvia Paola, Giudici, Fabiola, Strina, Carla, Sirico, Marianna, Bernocchi, Ottavia, Milani, Manuela, Ziglioli, Nicoletta, Aguggini, Sergio, Azzini, Carlo, Barbieri, Giuseppina, Cervoni, Valeria, Cappelletti, Maria Rosa, Molteni, Alfredo, Lazzari, Maria Chiara, Ferrero, Giuseppina, Ungari, Marco, Marasco, Elena, Bruson, Alice, Xumerle, Luciano, Zago, Elisa, Cerra, Davide, Loddo, Marco, Williams, Gareth H., Paris, Ida, Scambia, Giovanni, Generali, Daniele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273330/ https://www.ncbi.nlm.nih.gov/pubmed/34262869 http://dx.doi.org/10.3389/fonc.2021.686776

Ejemplares similares

Computational reactive–diffusive modeling for stratification and prognosis determination of patients with breast cancer receiving Olaparib
por: Schettini, Francesco, et al.
Publicado: (2023)

Tumor Type Agnostic Therapy Carrying BRAF Mutation: Case Reports and Review of Literature
por: Bernocchi, Ottavia, et al.
Publicado: (2021)

Impact of BMI on the outcome of metastatic breast cancer patients treated with everolimus: a retrospective exploratory analysis of the BALLET study
por: Corona, Silvia P., et al.
Publicado: (2020)

Addendum: Impact of BMI on the outcome of metastatic breast cancer patients treated with everolimus: a retrospective exploratory analysis of the BALLET study
por: Corona, Silvia P., et al.
Publicado: (2022)

Early Changes of the Standardized Uptake Values (SUV(max)) Predict the Efficacy of Everolimus-Exemestane in Patients with Hormone Receptor-Positive Metastatic Breast Cancer
por: Sirico, Marianna, et al.
Publicado: (2020)

Itaca e Oltre/
por: Magris, Claudio

Oltre la politica : antologia del pensiero "impolitico"
Publicado: (1996)

Role of the IGF-1 Axis in Overcoming Resistance in Breast Cancer
por: Ianza, Anna, et al.
Publicado: (2021)

Oltre il potere nostro : (Over Aevne) : dramma in due atti /
por: Björnson, Björnstjerne, 1832-1910
Publicado: (1895)

Oltre le nuove frontiere della fisica
por: Sullivan, W
Publicado: (1982)

Immune system and angiogenesis-related potential surrogate biomarkers of response to everolimus-based treatment in hormone receptor-positive breast cancer: an exploratory study
por: Schettini, Francesco, et al.
Publicado: (2020)

Research projects in dosimetry, treatment planning, patient alignment and radiometabolic treatments
por: Badano, L, et al.
Publicado: (1996)

Oltre lo spazio e il tempo: la nuova fisica
por: Lachièze-Rey, Marc
Publicado: (2004)

Fisica e oltre: incontri con i protagonisti (1920-1965)
por: Heisenberg, Werner
Publicado: (1984)

Ginevra, particelle di antimateria "conservate" per oltre ottanta ore
por: Falk, B
Publicado: (1978)

Gene expression profiling and FDG-PET radiomics uncover radiometabolic signatures associated with outcome in DLBCL
por: Mazzara, Saveria, et al.
Publicado: (2022)

Oltre il mito: Lamarck e le scienze naturali del suo tempo
por: di Gregorio, Mario A.
Publicado: (1986)

Ricerca di fisica oltre il Modello Standard in eventi con energia mancante e jet nell’esperimento ATLAS ad LHC
por: Lavorgna, Marco
Publicado: (2017)

Il buio oltre le stelle: l'esplorazione dei lati oscuri dell'universo
por: Balbi, Amedeo
Publicado: (2019)

[(11)C]MADAM Used as a Model for Understanding the Radiometabolism of Diphenyl Sulfide Radioligands for Positron Emission Tomography (PET)
por: Gourand, Fabienne, et al.
Publicado: (2015)

Pleural epithelioid angiosarcoma with lymphatic differentiation arisen after radiometabolic therapy for thyroid carcinoma: immunohistochemical findings and review of the literature
por: Cabibi, Daniela, et al.
Publicado: (2017)

PARP Inhibitors and Radiometabolic Approaches in Metastatic Castration-Resistant Prostate Cancer: What’s Now, What’s New, and What’s Coming?
por: Marchetti, Andrea, et al.
Publicado: (2022)

Increased pathological complete response rate after a long-term neoadjuvant letrozole treatment in postmenopausal oestrogen and/or progesterone receptor-positive breast cancer
por: Allevi, G, et al.
Publicado: (2013)

Hypoxia-related biological markers as predictors of epirubicin-based treatment responsiveness and resistance in locally advanced breast cancer
por: Milani, Manuela, et al.
Publicado: (2017)

L'avventura dell'universo: da Aristotele alla teoria dei quanti e oltre : una storia senza fine
por: Ferris, Timothy
Publicado: (1989)

A case of trichogerminoma: a rare cutaneous follicular neoplasm
por: Ungari, Marco, et al.
Publicado: (2021)

Il LEP: Il prodotto di circa 4'000 anni-uomo con la contribuzione de oltre 500 ditte europee
por: CERN Press Office. Geneva
Publicado: (1989)

Langerhans cell histiocytosis of an intra-mammary lymph node in an 18-year-old woman
por: Ungari, Marco, et al.
Publicado: (2020)

Combination of letrozole, metronomic cyclophosphamide and sorafenib is well-tolerated and shows activity in patients with primary breast cancer
por: Bazzola, L, et al.
Publicado: (2015)

Olaparib in the management of ovarian cancer
por: Bixel, Kristin, et al.
Publicado: (2015)

Olaparib in Epithelial Ovarian Cancer
por: Anastasia, Paula J.
Publicado: (2016)

Olaparib: Transcending mutational barriers
por: Chandna, Abhishek
Publicado: (2019)

Olaparib and somatic BRCA mutations
por: George, Angela, et al.
Publicado: (2017)

Clinico-Immunological Effects of a Single-Agent CDK4/6 Inhibitor in Advanced HR+/HER2− Breast Cancer Based on a Window of Opportunity Study
por: D’Angelo, Alberto, et al.
Publicado: (2022)

NeuN, a DNA-binding neuron-specific protein expressed by Merkel cell carcinoma: analysis of 15 cases
por: Ungari, Marco, et al.
Publicado: (2021)

Circulating cell-free nucleic acids as prognostic and therapy predictive tools for metastatic castrate-resistant prostate cancer
por: Sobhani, Navid, et al.
Publicado: (2020)

The combination of olaparib and camptothecin for effective radiosensitization
por: Miura, Katsutoshi, et al.
Publicado: (2012)

Mazzara S, Travaini L, Botta F, et al. Gene expression profiling and FDG-PET radiomics uncover radiometabolic signatures associated with outcome in DLBCL. Blood Adv. 2023;7(4):630-643.
Publicado: (2023)

Profile of olaparib in the treatment of advanced ovarian cancer
por: Chase, Dana M, et al.
Publicado: (2016)

Olaparib-Induced Immune-Mediated Liver Injury
por: Alshelleh, Mohammad, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_vtbc6sf8v7ed2uujs2qja2no43