Abnormal Tryptophan Metabolism in HIV and Mycobacterium tuberculosis Infection

Host metabolism has recently gained more attention for its roles in physiological functions and pathologic conditions. Of these, metabolic tryptophan disorders generate a pattern of abnormal metabolites that are implicated in various diseases. Here, we briefly highlight the recent advances regarding...

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Autores principales: Wang, Xiaolei, Mehra, Smriti, Kaushal, Deepak, Veazey, Ronald S., Xu, Huanbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273495/
https://www.ncbi.nlm.nih.gov/pubmed/34262540
http://dx.doi.org/10.3389/fmicb.2021.666227
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author Wang, Xiaolei
Mehra, Smriti
Kaushal, Deepak
Veazey, Ronald S.
Xu, Huanbin
author_facet Wang, Xiaolei
Mehra, Smriti
Kaushal, Deepak
Veazey, Ronald S.
Xu, Huanbin
author_sort Wang, Xiaolei
collection PubMed
description Host metabolism has recently gained more attention for its roles in physiological functions and pathologic conditions. Of these, metabolic tryptophan disorders generate a pattern of abnormal metabolites that are implicated in various diseases. Here, we briefly highlight the recent advances regarding abnormal tryptophan metabolism in HIV and Mycobacterium tuberculosis infection and discuss its potential impact on immune regulation, disease progression, and neurological disorders. Finally, we also discuss the potential for metabolic tryptophan interventions toward these infectious diseases.
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spelling pubmed-82734952021-07-13 Abnormal Tryptophan Metabolism in HIV and Mycobacterium tuberculosis Infection Wang, Xiaolei Mehra, Smriti Kaushal, Deepak Veazey, Ronald S. Xu, Huanbin Front Microbiol Microbiology Host metabolism has recently gained more attention for its roles in physiological functions and pathologic conditions. Of these, metabolic tryptophan disorders generate a pattern of abnormal metabolites that are implicated in various diseases. Here, we briefly highlight the recent advances regarding abnormal tryptophan metabolism in HIV and Mycobacterium tuberculosis infection and discuss its potential impact on immune regulation, disease progression, and neurological disorders. Finally, we also discuss the potential for metabolic tryptophan interventions toward these infectious diseases. Frontiers Media S.A. 2021-06-28 /pmc/articles/PMC8273495/ /pubmed/34262540 http://dx.doi.org/10.3389/fmicb.2021.666227 Text en Copyright © 2021 Wang, Mehra, Kaushal, Veazey and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Wang, Xiaolei
Mehra, Smriti
Kaushal, Deepak
Veazey, Ronald S.
Xu, Huanbin
Abnormal Tryptophan Metabolism in HIV and Mycobacterium tuberculosis Infection
title Abnormal Tryptophan Metabolism in HIV and Mycobacterium tuberculosis Infection
title_full Abnormal Tryptophan Metabolism in HIV and Mycobacterium tuberculosis Infection
title_fullStr Abnormal Tryptophan Metabolism in HIV and Mycobacterium tuberculosis Infection
title_full_unstemmed Abnormal Tryptophan Metabolism in HIV and Mycobacterium tuberculosis Infection
title_short Abnormal Tryptophan Metabolism in HIV and Mycobacterium tuberculosis Infection
title_sort abnormal tryptophan metabolism in hiv and mycobacterium tuberculosis infection
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273495/
https://www.ncbi.nlm.nih.gov/pubmed/34262540
http://dx.doi.org/10.3389/fmicb.2021.666227
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