Epigenetic Reprogramming of CD4(+) Helper T Cells as a Strategy to Improve Anticancer Immunotherapy

Evidences highlight the role of various CD4(+) helper T cells (CD4(+) Th) subpopulations in orchestrating the immune responses against cancers. Epigenetics takes an important part in the regulation of CD4(+) Th polarization and plasticity. In this review, we described the epigenetic factors that gov...

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Detalles Bibliográficos
Autores principales: Renaude, Elodie, Kroemer, Marie, Borg, Christophe, Peixoto, Paul, Hervouet, Eric, Loyon, Romain, Adotévi, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273698/
https://www.ncbi.nlm.nih.gov/pubmed/34262562
http://dx.doi.org/10.3389/fimmu.2021.669992
Descripción
Sumario:Evidences highlight the role of various CD4(+) helper T cells (CD4(+) Th) subpopulations in orchestrating the immune responses against cancers. Epigenetics takes an important part in the regulation of CD4(+) Th polarization and plasticity. In this review, we described the epigenetic factors that govern CD4(+) T cells differentiation and recruitment in the tumor microenvironment and their subsequent involvement in the antitumor immunity. Finally, we discussed how to manipulate tumor reactive CD4(+) Th responses by epigenetic drugs to improve anticancer immunotherapy.

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