Epigenetic Reprogramming of CD4(+) Helper T Cells as a Strategy to Improve Anticancer Immunotherapy

Evidences highlight the role of various CD4(+) helper T cells (CD4(+) Th) subpopulations in orchestrating the immune responses against cancers. Epigenetics takes an important part in the regulation of CD4(+) Th polarization and plasticity. In this review, we described the epigenetic factors that gov...

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Autores principales: Renaude, Elodie, Kroemer, Marie, Borg, Christophe, Peixoto, Paul, Hervouet, Eric, Loyon, Romain, Adotévi, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273698/
https://www.ncbi.nlm.nih.gov/pubmed/34262562
http://dx.doi.org/10.3389/fimmu.2021.669992
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author Renaude, Elodie
Kroemer, Marie
Borg, Christophe
Peixoto, Paul
Hervouet, Eric
Loyon, Romain
Adotévi, Olivier
author_facet Renaude, Elodie
Kroemer, Marie
Borg, Christophe
Peixoto, Paul
Hervouet, Eric
Loyon, Romain
Adotévi, Olivier
author_sort Renaude, Elodie
collection PubMed
description Evidences highlight the role of various CD4(+) helper T cells (CD4(+) Th) subpopulations in orchestrating the immune responses against cancers. Epigenetics takes an important part in the regulation of CD4(+) Th polarization and plasticity. In this review, we described the epigenetic factors that govern CD4(+) T cells differentiation and recruitment in the tumor microenvironment and their subsequent involvement in the antitumor immunity. Finally, we discussed how to manipulate tumor reactive CD4(+) Th responses by epigenetic drugs to improve anticancer immunotherapy.
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spelling pubmed-82736982021-07-13 Epigenetic Reprogramming of CD4(+) Helper T Cells as a Strategy to Improve Anticancer Immunotherapy Renaude, Elodie Kroemer, Marie Borg, Christophe Peixoto, Paul Hervouet, Eric Loyon, Romain Adotévi, Olivier Front Immunol Immunology Evidences highlight the role of various CD4(+) helper T cells (CD4(+) Th) subpopulations in orchestrating the immune responses against cancers. Epigenetics takes an important part in the regulation of CD4(+) Th polarization and plasticity. In this review, we described the epigenetic factors that govern CD4(+) T cells differentiation and recruitment in the tumor microenvironment and their subsequent involvement in the antitumor immunity. Finally, we discussed how to manipulate tumor reactive CD4(+) Th responses by epigenetic drugs to improve anticancer immunotherapy. Frontiers Media S.A. 2021-06-28 /pmc/articles/PMC8273698/ /pubmed/34262562 http://dx.doi.org/10.3389/fimmu.2021.669992 Text en Copyright © 2021 Renaude, Kroemer, Borg, Peixoto, Hervouet, Loyon and Adotévi https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Renaude, Elodie
Kroemer, Marie
Borg, Christophe
Peixoto, Paul
Hervouet, Eric
Loyon, Romain
Adotévi, Olivier
Epigenetic Reprogramming of CD4(+) Helper T Cells as a Strategy to Improve Anticancer Immunotherapy
title Epigenetic Reprogramming of CD4(+) Helper T Cells as a Strategy to Improve Anticancer Immunotherapy
title_full Epigenetic Reprogramming of CD4(+) Helper T Cells as a Strategy to Improve Anticancer Immunotherapy
title_fullStr Epigenetic Reprogramming of CD4(+) Helper T Cells as a Strategy to Improve Anticancer Immunotherapy
title_full_unstemmed Epigenetic Reprogramming of CD4(+) Helper T Cells as a Strategy to Improve Anticancer Immunotherapy
title_short Epigenetic Reprogramming of CD4(+) Helper T Cells as a Strategy to Improve Anticancer Immunotherapy
title_sort epigenetic reprogramming of cd4(+) helper t cells as a strategy to improve anticancer immunotherapy
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273698/
https://www.ncbi.nlm.nih.gov/pubmed/34262562
http://dx.doi.org/10.3389/fimmu.2021.669992
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