The Development of Disease-Modifying Therapies for Osteoarthritis (DMOADs): The Evidence to Date

Osteoarthritis (OA) is a complex heterogeneous articular disease with multiple joint tissue involvement of varying severity and no regulatory-agency-approved disease-modifying drugs (DMOADs). In this review, we discuss the reasons necessitating the development of DMOADs for OA management, the classi...

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Autores principales: Oo, Win Min, Little, Christopher, Duong, Vicky, Hunter, David J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273751/
https://www.ncbi.nlm.nih.gov/pubmed/34262259
http://dx.doi.org/10.2147/DDDT.S295224
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author Oo, Win Min
Little, Christopher
Duong, Vicky
Hunter, David J
author_facet Oo, Win Min
Little, Christopher
Duong, Vicky
Hunter, David J
author_sort Oo, Win Min
collection PubMed
description Osteoarthritis (OA) is a complex heterogeneous articular disease with multiple joint tissue involvement of varying severity and no regulatory-agency-approved disease-modifying drugs (DMOADs). In this review, we discuss the reasons necessitating the development of DMOADs for OA management, the classifications of clinical phenotypes or molecular/mechanistic endotypes from the viewpoint of targeted drug discovery, and then summarize the efficacy and safety profile of a range of targeted drugs in Phase 2 and 3 clinical trials directed to cartilage-driven, bone-driven, and inflammation-driven endotypes. Finally, we briefly put forward the reasons for failures in OA clinical trials and possible steps to overcome these barriers.
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spelling pubmed-82737512021-07-13 The Development of Disease-Modifying Therapies for Osteoarthritis (DMOADs): The Evidence to Date Oo, Win Min Little, Christopher Duong, Vicky Hunter, David J Drug Des Devel Ther Review Osteoarthritis (OA) is a complex heterogeneous articular disease with multiple joint tissue involvement of varying severity and no regulatory-agency-approved disease-modifying drugs (DMOADs). In this review, we discuss the reasons necessitating the development of DMOADs for OA management, the classifications of clinical phenotypes or molecular/mechanistic endotypes from the viewpoint of targeted drug discovery, and then summarize the efficacy and safety profile of a range of targeted drugs in Phase 2 and 3 clinical trials directed to cartilage-driven, bone-driven, and inflammation-driven endotypes. Finally, we briefly put forward the reasons for failures in OA clinical trials and possible steps to overcome these barriers. Dove 2021-07-06 /pmc/articles/PMC8273751/ /pubmed/34262259 http://dx.doi.org/10.2147/DDDT.S295224 Text en © 2021 Oo et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Oo, Win Min
Little, Christopher
Duong, Vicky
Hunter, David J
The Development of Disease-Modifying Therapies for Osteoarthritis (DMOADs): The Evidence to Date
title The Development of Disease-Modifying Therapies for Osteoarthritis (DMOADs): The Evidence to Date
title_full The Development of Disease-Modifying Therapies for Osteoarthritis (DMOADs): The Evidence to Date
title_fullStr The Development of Disease-Modifying Therapies for Osteoarthritis (DMOADs): The Evidence to Date
title_full_unstemmed The Development of Disease-Modifying Therapies for Osteoarthritis (DMOADs): The Evidence to Date
title_short The Development of Disease-Modifying Therapies for Osteoarthritis (DMOADs): The Evidence to Date
title_sort development of disease-modifying therapies for osteoarthritis (dmoads): the evidence to date
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273751/
https://www.ncbi.nlm.nih.gov/pubmed/34262259
http://dx.doi.org/10.2147/DDDT.S295224
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