Cargando…
Liver Stiffness Measurement by Using Transient Elastography in Bangladeshi Patients with Type 2 Diabetes Mellitus and Ultrasonography-Diagnosed Nonalcoholic Fatty Liver Disease
PURPOSE: Type 2 diabetes mellitus (T2DM) is associated with an increased risk of nonalcoholic fatty liver disease (NAFLD), and the presence of T2DM tremendously drives NAFLD progression. The use of transient elastography (TE) for assessment of NAFLD has been increasing due to its high sensitivity an...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273900/ https://www.ncbi.nlm.nih.gov/pubmed/34262313 http://dx.doi.org/10.2147/DMSO.S317876 |
_version_ | 1783721463916789760 |
---|---|
author | Alam, Muhammad Shah Kamrul-Hasan, A B M Kalam, Syeda Tanzina Rahman, S M Mizanur Hoque, Mohammad Izazul Islam, Md Belalul Paul, Ajit Kumar |
author_facet | Alam, Muhammad Shah Kamrul-Hasan, A B M Kalam, Syeda Tanzina Rahman, S M Mizanur Hoque, Mohammad Izazul Islam, Md Belalul Paul, Ajit Kumar |
author_sort | Alam, Muhammad Shah |
collection | PubMed |
description | PURPOSE: Type 2 diabetes mellitus (T2DM) is associated with an increased risk of nonalcoholic fatty liver disease (NAFLD), and the presence of T2DM tremendously drives NAFLD progression. The use of transient elastography (TE) for assessment of NAFLD has been increasing due to its high sensitivity and specificity. This study aimed to measure liver stiffness in patients with T2DM and ultrasonography (USG)-diagnosed NAFLD and assess the correlations between liver stiffness and other clinical and biochemical parameters. PATIENTS AND METHODS: This cross-sectional study assessed 205 adult patients with T2DM and USG-diagnosed NAFLD who were being treated at a specialized endocrine private practice in Bangladesh. All subjects underwent TE for hepatic fibrosis assessment, which was performed using a FibroScan(®) 402 device. A fibrosis score ≥9.7 kilopascals (kPa) was used to define advanced fibrosis (≥F3). RESULTS: Out of 205 (65.9% female, mean age 45 ± 27 years, 67.3% obese) patients, the frequencies of Grade 1, Grade 2, and Grade 3 fatty liver on USG were 46.3%, 51.2%, and 2.4%, respectively. According to the TE results, 41 (20%) had advanced fibrosis (≥F3). Subjects with advanced fibrosis had a higher body mass index (BMI), higher levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and higher frequencies of individuals with elevated ALT and AST and advanced fatty liver grades on USG. The fibrosis score (kPa) was strongly and positively correlated with age, BMI, waist circumference, obesity, serum ALT and AST levels, and the fatty liver grade in USG; the AST:ALT ratio did not correlate with kPa. CONCLUSION: The data showed that 20% of the subjects with T2DM having NAFLD on USG exhibited advanced fibrosis, demonstrating the need for early diagnosis and treatment of NAFLD in T2DM. The use of TE with other serum markers can be helpful for the diagnosis of advanced fibrosis. |
format | Online Article Text |
id | pubmed-8273900 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-82739002021-07-13 Liver Stiffness Measurement by Using Transient Elastography in Bangladeshi Patients with Type 2 Diabetes Mellitus and Ultrasonography-Diagnosed Nonalcoholic Fatty Liver Disease Alam, Muhammad Shah Kamrul-Hasan, A B M Kalam, Syeda Tanzina Rahman, S M Mizanur Hoque, Mohammad Izazul Islam, Md Belalul Paul, Ajit Kumar Diabetes Metab Syndr Obes Original Research PURPOSE: Type 2 diabetes mellitus (T2DM) is associated with an increased risk of nonalcoholic fatty liver disease (NAFLD), and the presence of T2DM tremendously drives NAFLD progression. The use of transient elastography (TE) for assessment of NAFLD has been increasing due to its high sensitivity and specificity. This study aimed to measure liver stiffness in patients with T2DM and ultrasonography (USG)-diagnosed NAFLD and assess the correlations between liver stiffness and other clinical and biochemical parameters. PATIENTS AND METHODS: This cross-sectional study assessed 205 adult patients with T2DM and USG-diagnosed NAFLD who were being treated at a specialized endocrine private practice in Bangladesh. All subjects underwent TE for hepatic fibrosis assessment, which was performed using a FibroScan(®) 402 device. A fibrosis score ≥9.7 kilopascals (kPa) was used to define advanced fibrosis (≥F3). RESULTS: Out of 205 (65.9% female, mean age 45 ± 27 years, 67.3% obese) patients, the frequencies of Grade 1, Grade 2, and Grade 3 fatty liver on USG were 46.3%, 51.2%, and 2.4%, respectively. According to the TE results, 41 (20%) had advanced fibrosis (≥F3). Subjects with advanced fibrosis had a higher body mass index (BMI), higher levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and higher frequencies of individuals with elevated ALT and AST and advanced fatty liver grades on USG. The fibrosis score (kPa) was strongly and positively correlated with age, BMI, waist circumference, obesity, serum ALT and AST levels, and the fatty liver grade in USG; the AST:ALT ratio did not correlate with kPa. CONCLUSION: The data showed that 20% of the subjects with T2DM having NAFLD on USG exhibited advanced fibrosis, demonstrating the need for early diagnosis and treatment of NAFLD in T2DM. The use of TE with other serum markers can be helpful for the diagnosis of advanced fibrosis. Dove 2021-07-06 /pmc/articles/PMC8273900/ /pubmed/34262313 http://dx.doi.org/10.2147/DMSO.S317876 Text en © 2021 Alam et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Alam, Muhammad Shah Kamrul-Hasan, A B M Kalam, Syeda Tanzina Rahman, S M Mizanur Hoque, Mohammad Izazul Islam, Md Belalul Paul, Ajit Kumar Liver Stiffness Measurement by Using Transient Elastography in Bangladeshi Patients with Type 2 Diabetes Mellitus and Ultrasonography-Diagnosed Nonalcoholic Fatty Liver Disease |
title | Liver Stiffness Measurement by Using Transient Elastography in Bangladeshi Patients with Type 2 Diabetes Mellitus and Ultrasonography-Diagnosed Nonalcoholic Fatty Liver Disease |
title_full | Liver Stiffness Measurement by Using Transient Elastography in Bangladeshi Patients with Type 2 Diabetes Mellitus and Ultrasonography-Diagnosed Nonalcoholic Fatty Liver Disease |
title_fullStr | Liver Stiffness Measurement by Using Transient Elastography in Bangladeshi Patients with Type 2 Diabetes Mellitus and Ultrasonography-Diagnosed Nonalcoholic Fatty Liver Disease |
title_full_unstemmed | Liver Stiffness Measurement by Using Transient Elastography in Bangladeshi Patients with Type 2 Diabetes Mellitus and Ultrasonography-Diagnosed Nonalcoholic Fatty Liver Disease |
title_short | Liver Stiffness Measurement by Using Transient Elastography in Bangladeshi Patients with Type 2 Diabetes Mellitus and Ultrasonography-Diagnosed Nonalcoholic Fatty Liver Disease |
title_sort | liver stiffness measurement by using transient elastography in bangladeshi patients with type 2 diabetes mellitus and ultrasonography-diagnosed nonalcoholic fatty liver disease |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273900/ https://www.ncbi.nlm.nih.gov/pubmed/34262313 http://dx.doi.org/10.2147/DMSO.S317876 |
work_keys_str_mv | AT alammuhammadshah liverstiffnessmeasurementbyusingtransientelastographyinbangladeshipatientswithtype2diabetesmellitusandultrasonographydiagnosednonalcoholicfattyliverdisease AT kamrulhasanabm liverstiffnessmeasurementbyusingtransientelastographyinbangladeshipatientswithtype2diabetesmellitusandultrasonographydiagnosednonalcoholicfattyliverdisease AT kalamsyedatanzina liverstiffnessmeasurementbyusingtransientelastographyinbangladeshipatientswithtype2diabetesmellitusandultrasonographydiagnosednonalcoholicfattyliverdisease AT rahmansmmizanur liverstiffnessmeasurementbyusingtransientelastographyinbangladeshipatientswithtype2diabetesmellitusandultrasonographydiagnosednonalcoholicfattyliverdisease AT hoquemohammadizazul liverstiffnessmeasurementbyusingtransientelastographyinbangladeshipatientswithtype2diabetesmellitusandultrasonographydiagnosednonalcoholicfattyliverdisease AT islammdbelalul liverstiffnessmeasurementbyusingtransientelastographyinbangladeshipatientswithtype2diabetesmellitusandultrasonographydiagnosednonalcoholicfattyliverdisease AT paulajitkumar liverstiffnessmeasurementbyusingtransientelastographyinbangladeshipatientswithtype2diabetesmellitusandultrasonographydiagnosednonalcoholicfattyliverdisease |