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Atherogenic index of plasma is related to coronary atherosclerotic disease in elderly individuals: a cross-sectional study
BACKGROUND: Dyslipidaemia plays an important role in coronary atherosclerotic disease (CAD). The relationship between the atherogenic index of plasma (AIP) and CAD in elderly individuals was explored in this study. METHODS: Elderly individuals (age ≥ 65 years) who underwent coronary angiography from...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273949/ https://www.ncbi.nlm.nih.gov/pubmed/34247637 http://dx.doi.org/10.1186/s12944-021-01496-8 |
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author | Huang, Haomin Yu, Xiaolong Li, Lamei Shi, Ganwei Li, Feng Xiao, Jianqiang Yun, Zhihua Cai, Gaojun |
author_facet | Huang, Haomin Yu, Xiaolong Li, Lamei Shi, Ganwei Li, Feng Xiao, Jianqiang Yun, Zhihua Cai, Gaojun |
author_sort | Huang, Haomin |
collection | PubMed |
description | BACKGROUND: Dyslipidaemia plays an important role in coronary atherosclerotic disease (CAD). The relationship between the atherogenic index of plasma (AIP) and CAD in elderly individuals was explored in this study. METHODS: Elderly individuals (age ≥ 65 years) who underwent coronary angiography from January 2016 to October 2020 were consecutively enrolled in the study. RESULTS: A total of 1313 individuals, including 354 controls (non-CAD) and 959 CAD patients, were enrolled. In univariate analysis of all populations, the adjusted AIP (aAIP) in the CAD group was 1.13 (0.96, 1.3), which was significantly higher than that in the controls [1.07 (0.89, 1.26)]. However, in subgroup analyses, this phenomenon was only present in males. In addition, further study showed that aAIP was positively related to CAD severity. In binary logistic regression analyses, after adjusting for sex, age, smoking status, primary hypertension (PH), type 2 diabetes mellitus (T2DM), heart rate (HR), white blood cell (WBC) and platelet (PLT), AIP remained independently related to CAD in elderly individuals and was superior to traditional and other nontraditional lipid indices. Subgroup analyses showed that AIP independently influenced CAD risk in males. Ultimately, sensitivity analyses were performed excluding all coronary emergencies, and the final results were similar. CONCLUSIONS: AIP was positively related to the risk and severity of CAD in elderly individuals and was superior to traditional and other nontraditional lipid profiles. However, this association only exists in elderly males. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12944-021-01496-8. |
format | Online Article Text |
id | pubmed-8273949 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-82739492021-07-12 Atherogenic index of plasma is related to coronary atherosclerotic disease in elderly individuals: a cross-sectional study Huang, Haomin Yu, Xiaolong Li, Lamei Shi, Ganwei Li, Feng Xiao, Jianqiang Yun, Zhihua Cai, Gaojun Lipids Health Dis Research BACKGROUND: Dyslipidaemia plays an important role in coronary atherosclerotic disease (CAD). The relationship between the atherogenic index of plasma (AIP) and CAD in elderly individuals was explored in this study. METHODS: Elderly individuals (age ≥ 65 years) who underwent coronary angiography from January 2016 to October 2020 were consecutively enrolled in the study. RESULTS: A total of 1313 individuals, including 354 controls (non-CAD) and 959 CAD patients, were enrolled. In univariate analysis of all populations, the adjusted AIP (aAIP) in the CAD group was 1.13 (0.96, 1.3), which was significantly higher than that in the controls [1.07 (0.89, 1.26)]. However, in subgroup analyses, this phenomenon was only present in males. In addition, further study showed that aAIP was positively related to CAD severity. In binary logistic regression analyses, after adjusting for sex, age, smoking status, primary hypertension (PH), type 2 diabetes mellitus (T2DM), heart rate (HR), white blood cell (WBC) and platelet (PLT), AIP remained independently related to CAD in elderly individuals and was superior to traditional and other nontraditional lipid indices. Subgroup analyses showed that AIP independently influenced CAD risk in males. Ultimately, sensitivity analyses were performed excluding all coronary emergencies, and the final results were similar. CONCLUSIONS: AIP was positively related to the risk and severity of CAD in elderly individuals and was superior to traditional and other nontraditional lipid profiles. However, this association only exists in elderly males. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12944-021-01496-8. BioMed Central 2021-07-11 /pmc/articles/PMC8273949/ /pubmed/34247637 http://dx.doi.org/10.1186/s12944-021-01496-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Huang, Haomin Yu, Xiaolong Li, Lamei Shi, Ganwei Li, Feng Xiao, Jianqiang Yun, Zhihua Cai, Gaojun Atherogenic index of plasma is related to coronary atherosclerotic disease in elderly individuals: a cross-sectional study |
title | Atherogenic index of plasma is related to coronary atherosclerotic disease in elderly individuals: a cross-sectional study |
title_full | Atherogenic index of plasma is related to coronary atherosclerotic disease in elderly individuals: a cross-sectional study |
title_fullStr | Atherogenic index of plasma is related to coronary atherosclerotic disease in elderly individuals: a cross-sectional study |
title_full_unstemmed | Atherogenic index of plasma is related to coronary atherosclerotic disease in elderly individuals: a cross-sectional study |
title_short | Atherogenic index of plasma is related to coronary atherosclerotic disease in elderly individuals: a cross-sectional study |
title_sort | atherogenic index of plasma is related to coronary atherosclerotic disease in elderly individuals: a cross-sectional study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273949/ https://www.ncbi.nlm.nih.gov/pubmed/34247637 http://dx.doi.org/10.1186/s12944-021-01496-8 |
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