Rational Control of Molecular Properties Is Mandatory to Exploit the Potential of PROTACs as Oral Drugs

[Image: see text] To obtain new oral drugs in the beyond rule of five space, PROTACs among others, molecular properties should be optimized in early drug discovery. Degraders call for design strategies which focus on intramolecular interaction and chameleonicity. In parallel, tailored revalidation o...

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Detalles Bibliográficos
Autores principales: Ermondi, Giuseppe, Garcia Jimenez, Diego, Rossi Sebastiano, Matteo, Caron, Giulia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8274089/
https://www.ncbi.nlm.nih.gov/pubmed/34262642
http://dx.doi.org/10.1021/acsmedchemlett.1c00298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8274089/
https://www.ncbi.nlm.nih.gov/pubmed/34262642
http://dx.doi.org/10.1021/acsmedchemlett.1c00298

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