Cargando…

Metformin Antagonizes Ovarian Cancer Cells Malignancy Through MSLN Mediated IL-6/STAT3 Signaling

BACKGROUND: Ovarian cancer is the most lethal gynecological malignancy, and chemotherapy remains the cornerstone for ovarian cancer management. Due to the unsatisfactory prognosis, a better understanding of the underlying molecular carcinogenesis is urgently required. METHODS: Assays for determining...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Xu, Huang, Mei, Zhang, Qin, Chen, Jiao, Li, Juan, Han, Qian, Zhang, Lu, Li, JiaQi, Liu, Shuai, Ma, YuLan, Li, Lan, Yang, Lei, Zou, SiYing, Han, Bin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8274104/ https://www.ncbi.nlm.nih.gov/pubmed/34238029 http://dx.doi.org/10.1177/09636897211027819

Ejemplares similares

Tandem CAR-T cells targeting FOLR1 and MSLN enhance the antitumor effects in ovarian cancer
por: Liang, Zhen, et al.
Publicado: (2021)

MSLN Correlates With Immune Infiltration and Chemoresistance as a Prognostic Biomarker in Ovarian Cancer
por: Li, Yike, et al.
Publicado: (2022)

A MSLN-targeted multifunctional nanoimmunoliposome for MRI and targeting therapy in pancreatic cancer
por: Deng, Li, et al.
Publicado: (2012)

HLA-DR Presentation of the Tumor Antigen MSLN Associates with Clinical Outcome of Ovarian Cancer Patients
por: Tegeler, Christian M., et al.
Publicado: (2022)

Tuned activation of MSLN-CAR T cells induces superior antitumor responses in ovarian cancer models
por: Schoutrop, Esther, et al.
Publicado: (2023)

Elevated LINC00909 Promotes Tumor Progression of Ovarian Cancer via Regulating the miR-23b-3p/MRC2 Axis
por: Yang, Xu, et al.
Publicado: (2021)

A NOVEL MSLN×4-1BB BISPECIFIC ANTIBODY FOR SOLID TUMOR
por: Cheng, Liansheng, et al.
Publicado: (2023)

Trogocytosis and fratricide killing impede MSLN-directed CAR T cell functionality
por: Schoutrop, Esther, et al.
Publicado: (2022)

Effects of hsa-mir-145-5p on the Regulation of msln Expression in Colorectal Adenocarcinoma
por: Li, Junhua, et al.
Publicado: (2022)

A Novel PD-L1-Containing MSLN Targeting Vaccine for Lung Cancer Immunotherapy
por: Zeng, Wuyi, et al.
Publicado: (2022)

Antagonism of Interleukin-17A ameliorates experimental hepatic fibrosis by restoring the IL-10/STAT3-suppressed autophagy in hepatocytes
por: Zhang, Xiao-Wei, et al.
Publicado: (2016)

Evaluation of Soluble Mesothelin-related Peptides and MSLN Genetic Variability in Asbestos-related Diseases
por: Goricar, Katja, et al.
Publicado: (2020)

MSLN Gene Silencing Has an Anti-Malignant Effect on Cell Lines Overexpressing Mesothelin Deriving from Malignant Pleural Mesothelioma
por: Melaiu, Ombretta, et al.
Publicado: (2014)

Correction: MSLN gene silencing has an anti-malignant effect on cell lines overexpressing mesothelin deriving from malignant pleural mesothelioma
por: Melaiu, Ombretta, et al.
Publicado: (2017)

NS5-independent Ablation of STAT2 by Zika virus to antagonize interferon signalling
por: Shu, Jun, et al.
Publicado: (2021)

Metformin improves the sensitivity of ovarian cancer cells to chemotherapeutic agents
por: Yang, Chen, et al.
Publicado: (2019)

One Third of Malignant Pleural Mesothelioma Shows High Immunohistochemical Expression of MSLN or CXCR4 Which Indicates Potent Candidates for Endo-Radiotherapy
por: Hager, Thomas, et al.
Publicado: (2023)

Antagonizing STAT5B dimerization with an osmium complex
por: Liu, Li-Juan, et al.
Publicado: (2016)

Fingolimod inhibits proliferation and epithelial–mesenchymal transition in sacral chordoma by inactivating IL-6/STAT3 signalling
por: Wang, Jiaqi, et al.
Publicado: (2020)

IL-2–mTORC1 signaling coordinates the STAT1/T-bet axis to ensure Th1 cell differentiation and anti-bacterial immune response in fish
por: Ai, Kete, et al.
Publicado: (2022)

Comparison of the Diagnostic Accuracy of the MSLN Gene Products, Mesothelin and Megakaryocyte Potentiating Factor, as Biomarkers for Mesothelioma in Pleural Effusions and Serum
por: Creaney, Jenette, et al.
Publicado: (2013)

Metformin attenuates fibroblast activation during pulmonary fibrosis by targeting S100A4 via AMPK-STAT3 axis
por: Ji, Huimin, et al.
Publicado: (2023)

Antagonizing cytokine-mediated JAK-STAT signaling by porcine reproductive and respiratory syndrome virus
por: Yang, Liping, et al.
Publicado: (2017)

Antagonism of STAT3 signalling by Ebola virus
por: Harrison, Angela R., et al.
Publicado: (2021)

IL-17 Promotes Angiogenic Factors IL-6, IL-8, and Vegf Production via Stat1 in Lung Adenocarcinoma
por: Huang, Qi, et al.
Publicado: (2016)

Different role of MSLN and CA125 co-expression as a prognostic predictor between perihilar and distal bile duct carcinoma
por: Takihata, Yasuhiro, et al.
Publicado: (2021)

Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin
por: Ng, Dominic Chi Hiung, et al.
Publicado: (2006)

STAT4 targets KISS1 to promote the apoptosis of ovarian granulosa cells
por: Jiang, Yao, et al.
Publicado: (2020)

Corrigendum: IL-17 Promotes Angiogenic Factors IL-6, IL-8, and Vegf Production via Stat1 in Lung Adenocarcinoma
por: Huang, Qi, et al.
Publicado: (2017)

Phlorizin from sweet tea inhibits the progress of esophageal cancer by antagonizing the JAK2/STAT3 signaling pathway
por: Jia, Zhenxian, et al.
Publicado: (2021)

Human Papillomavirus Infection Correlates with Inflammatory Stat3 Signaling Activity and IL-17 Level in Patients with Colorectal Cancer
por: Li, Yi Xin, et al.
Publicado: (2015)

Metformin reverses prostate cancer resistance to enzalutamide by targeting TGF-β1/STAT3 axis-regulated EMT
por: Liu, Qiuli, et al.
Publicado: (2017)

Long non-coding RNA THOR promotes ovarian Cancer cells progression via IL-6/STAT3 pathway
por: Ge, Jing, et al.
Publicado: (2020)

Overexpression of NPTX2 Promotes Malignant Phenotype of Epithelial Ovarian Carcinoma via IL6-JAK2/STAT3 Signaling Pathway Under Hypoxia
por: Han, Xiaotian, et al.
Publicado: (2021)

Metformin promotes ferroptosis and sensitivity to sorafenib in hepatocellular carcinoma cells via ATF4/STAT3
por: Hu, Zongqiang, et al.
Publicado: (2023)

Effect of metformin versus metformin plus liraglutide on gonadal and metabolic profiles in overweight patients with polycystic ovary syndrome
por: Xing, Chuan, et al.
Publicado: (2022)

Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis
por: Griss, Takla, et al.
Publicado: (2015)

Dual inhibition of EGFR and IL-6-STAT3 signalling by miR-146b: a potential targeted therapy for epithelial ovarian cancer
por: Yan, Meina, et al.
Publicado: (2021)

Effect of metformin on the proliferation, apoptosis, invasion and autophagy of ovarian cancer cells
por: Zou, Ge, et al.
Publicado: (2019)

TMED3 promotes hepatocellular carcinoma progression via IL-11/STAT3 signaling
por: Zheng, Hao, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_55a8ui4ukh4fel5pp8usb0hopb