CCR8 marks highly suppressive Treg cells within tumours but is dispensable for their accumulation and suppressive function

CD4(+) regulatory T (Treg) cells, dependent upon the transcription factor Foxp3, contribute to tumour immunosuppression but are also required for immune homeostasis. There is interest in developing therapies that selectively target the immunosuppressive function of Treg cells within tumours without...

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Detalles Bibliográficos
Autores principales: Whiteside, Sarah K., Grant, Francis M., Gyori, David S., Conti, Alberto G., Imianowski, Charlotte J., Kuo, Paula, Nasrallah, Rabab, Sadiyah, Firas, Lira, Sergio A., Tacke, Frank, Eil, Robert L., Burton, Oliver T., Dooley, James, Liston, Adrian, Okkenhaug, Klaus, Yang, Jie, Roychoudhuri, Rahul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8274197/
https://www.ncbi.nlm.nih.gov/pubmed/33838058
http://dx.doi.org/10.1111/imm.13337

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