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CD21(low) B cells are predictive markers of new digital ulcers in systemic sclerosis

The objective of this study was to evaluate the predictive role of CD21(low) B cells as markers of new digital ulcers in systemic sclerosis patients. Peripheral blood B cell subpopulations and clinical assessments have been evaluated in 74 systemic sclerosis patients at baseline and after a 12‐month...

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Detalles Bibliográficos
Autores principales: Visentini, Marcella, Pellicano, Chiara, Leodori, Giorgia, Marrapodi, Ramona, Colantuono, Stefania, Gigante, Antonietta, Casato, Milvia, Rosato, Edoardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8274201/
https://www.ncbi.nlm.nih.gov/pubmed/33876421
http://dx.doi.org/10.1111/cei.13604
Descripción
Sumario:The objective of this study was to evaluate the predictive role of CD21(low) B cells as markers of new digital ulcers in systemic sclerosis patients. Peripheral blood B cell subpopulations and clinical assessments have been evaluated in 74 systemic sclerosis patients at baseline and after a 12‐month follow‐up. After a 12‐month follow‐up, 23 (31.1%) systemic sclerosis patients developed new digital ulcers. The median percentage of CD21(low) B cells was significantly higher in patients with than without new digital ulcers [10.1 (4.3–13.6) versus 4.8 (3.5–7.4); p < 0.01]. The 10% cut‐off shows good diagnostic accuracy [area under the curve (AUC) = 0.732, confidence interval (CI) = 0.587–0.878; P = 0.01]. Kaplan–Meier curves show a significantly reduced free survival from new digital ulcers in systemic sclerosis patients with CD21(low) B cells ≥ 10% (p < 0.0001). In multivariate analysis, CD21(low) B cells ≥ 10%, modified Rodnan skin score (mRSS) and systolic pulmonary arterial pressure (sPAP) are associated with the development of new digital ulcers. We hypothesize that CD21(low) B cells are a predictive marker of new digital ulcers in systemic sclerosis patients.