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K(ATP) channel blockers control glucagon secretion by distinct mechanisms: A direct stimulation of α-cells involving a [Ca(2+)](c) rise and an indirect inhibition mediated by somatostatin

OBJECTIVE: Glucagon is secreted by pancreatic α-cells in response to hypoglycemia and its hyperglycemic effect helps to restore normal blood glucose. Insulin and somatostatin (SST) secretions from β- and δ-cells, respectively, are stimulated by glucose by mechanisms involving an inhibition of their...

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Detalles Bibliográficos
Autores principales:	Singh, Bilal, Khattab, Firas, Chae, Heeyoung, Desmet, Lieven, Herrera, Pedro L., Gilon, Patrick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8274344/ https://www.ncbi.nlm.nih.gov/pubmed/34118477 http://dx.doi.org/10.1016/j.molmet.2021.101268

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